| 糖皮质激素对鼻息肉缺氧诱导因子-1α及血管内皮生长因子表达的影响 |
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| 引用本文： | 李臻. 糖皮质激素对鼻息肉缺氧诱导因子-1α及血管内皮生长因子表达的影响[J]. 山东大学耳鼻喉眼学报, 2011, 25(1): 53 |
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| 作者姓名： | 李臻 |
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| 作者单位： | 烟台市烟台山医院耳鼻喉科, 山东 烟台 264001 |
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| 摘 要： | 目的 探讨组织缺氧诱导因子-1α(HIF-1α）及血管内皮生长因子（VEGF）在鼻息肉组织中的表达及相关性, 探讨局部应用糖皮质激素类药物对鼻息肉的作用机制。方法 采用免疫组化SP法检测鼻息肉组织在应用丙酸氟替卡松鼻喷剂治疗前、后及下鼻甲HIF-1α及VEGF的表达变化。结果 鼻息肉组织中HIF-1α和VEGF的表达水平明显高于下鼻甲组织（P均＜0.01）；激素治疗后HIF-1α、VEGF表达下降(P＜0.05)。鼻息肉的发病与组织中HIF-1α、VEGF的表达呈明显正相关（r=0.627, P＜0.05）。结论 局部应用糖皮质激素可降低HIF 1α、VEGF的表达，有效治疗鼻息肉。
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| 关 键 词： | 糖皮质激素；鼻息肉；缺氧诱导因子 1α；血管内皮生长因子 |
| 收稿时间： | 2010-06-23 |
| 修稿时间： | 2010-12-26 |
Effects of corticosteroid on expressions of HIF-1α and VEGF in nasal polyps |
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| LI Zhen. Effects of corticosteroid on expressions of HIF-1α and VEGF in nasal polyps[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2011, 25(1): 53 |
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| Authors: | LI Zhen |
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| Affiliation: | Department of Otorhinolaryngology, Yantaishan Hospital, Yantai 264001, Shandong, China |
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| Abstract: | Objective To study expression and relationship of hypoxia-inducible factor-1α （HIF-1α） and vessel endothelium growth factor（VEGF ）in nasal polyps, and to investigate the mechanism of action of corticosteroid on these cell factors. Methods Expressions of HIF-1α and VEGF in nasal polyps before and after treatment with corticosteroid were detected by SP immunohistochemical methods, and their relationship was calculated by linear correlation analysis. Results Expressions of HIF 1α and VEGF in nasal polyps were higher than those in inferior turbinate tissues. Expressions of HIF-1α and VEGF were significantly reduced in nasal polyps after treatment with corticosteroid. There was a positive correlation between expression of HIF-1α and that of VEGF. Conclusion Corticosteroid is effective in nasal polyps by restraining expressions of HIF-1α and VEGF. |
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| Keywords: | Corticosteroid Nasal polyps Hypoxia inducible factor Vessel endothelium growth factor |
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