Past and future impact of next‐generation sequencing in head and neck cancer |
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| Authors: | Neeraj Sethi MB ChB Kenneth MacLennan MD Henry M. Wood PhD Pamela Rabbitts PhD |
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| Affiliation: | Leeds Institute of Cancer and Pathology, Wellcome Trust Brenner Building, St. James’ University Hospital, Leeds, West Yorkshire, United Kingdom |
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| Abstract: | Progress in sequencing technology is intrinsically linked to progress in understanding cancer genomics. The purpose of this review was to discuss the development from Sanger sequencing to next‐generation sequencing (NGS) technology. We highlight the technical considerations for understanding reports using NGS. We discuss the findings of studies in head and neck cancer using NGS as well as The Cancer Genome Atlas. Finally we discuss future routes for research utilizing this methodology and the potential impact of this. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E2395–E2402, 2016 |
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| Keywords: | next‐generation sequencing head and neck cancer Sanger sequencing human papillomavirus genomics |
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