| IL-28B rs12979860位点与乙肝病毒感染后自发清除及干扰素治疗应答关系的Meta分析 |
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| 引用本文： | 于风雪, 姜乐, 马宁, 张晓琳, 权媛, 刘殿武. IL-28B rs12979860位点与乙肝病毒感染后自发清除及干扰素治疗应答关系的Meta分析[J]. 中华疾病控制杂志, 2016, 20(7): 707-711. doi: 10.16462/j.cnki.zhjbkz.2016.07.016 |
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| 作者姓名： | 于风雪 姜乐 马宁 张晓琳 权媛 刘殿武 |
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| 作者单位： | 1. 河北医科大学第二医院科研处, 河北 石家庄 050000;;2. 河北医科大学流行病学教研室, 河北 石家庄 050017;;3. 河北省胸科医院结核科, 河北 石家庄 050041 |
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| 基金项目： | 国家自然科学基金青年科学基金(81402729)，河北省自然科学基金(H2015206152)，河北省科技厅课题(13277732D) |
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| 摘 要： | 目的 探索白细胞介素28B（interleukin- 28B，IL-28B）基因rs12979860位点与乙型肝炎病毒（hepatitis B virus，HBV）感染后自发清除及干扰素治疗应答的关系。方法 检索2010年1月1日～2015年8月31日PubMed、Embase、中文科技期刊全文数据库、万方数据库、中国生物医学文献数据库、中国期刊全文数据库公开发表文献，对符合纳入和排除标准文献提取数据后采用Stata 12.0 软件进行Meta分析。结果 共纳入12篇文献，根据研究目的分为两组：A组为HBV自发清除组和持续感染组，共5篇文献；B组：干扰素治疗应答组和非应答组，共9篇文献。Meta分析结果：rs12979860位点与HBV感染后自发清除无关联（OR=0.96，95% CI：0.76～1.20，P=0.700）；rs12979860位点与乙型肝炎e抗原阳性慢性HBV感染后干扰素治疗应答无关联（OR=0.93,95% CI：0.43～2.00，P=0.848），而突变基因型TC+TT 降低了乙型肝炎e抗原阴性慢性HBV感染后干扰素治疗应答（OR=0.47,95% CI：0.25～0.87，P=0.016）。结论 IL-28B基因的rs12979860位点突变基因型TC+TT降低了乙型肝炎e抗原阴性慢性HBV感染后干扰素治疗的应答。
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| 关 键 词： | 基因 肝炎 乙型 慢性 Meta分析 |
| 收稿时间： | 2016-01-15 |
| 修稿时间： | 2016-04-20 |
Association of IL-28B rs12979860 with spontaneous HBV clearance and interferon treatment response: a Meta-analysis |
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| YU Feng-xue, JIANG Le, MA Ning, ZHANG Xiao-lin, QUAN Yuan, LIU Dian-wu. Association of IL-28B rs12979860 with spontaneous HBV clearance and interferon treatment response: a Meta-analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(7): 707-711. doi: 10.16462/j.cnki.zhjbkz.2016.07.016 |
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| Authors: | YU Feng-xue JIANG Le MA Ning ZHANG Xiao-lin QUAN Yuan LIU Dian-wu |
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| Affiliation: | 1. Department of Science and Technology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China;;2. Department of Epidemiology, Hebei Medical University, Shijiazhuang 050017, China;;3. Department of Tuberculosis, the Chest Hospital of Hebei Province, Shijiazhuang 050041, China |
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| Abstract: | Objective To investigate the association of SNP-rs12979860 in Interleukin- 28B (IL-28B) gene with spontaneous Hepatitis B Virus (HBV)clearance and interferon treatment response in patients with chronic hepatitis B. Methods Data published from January 1, 2010 to August 31, 2015 were retrieved from PubMed,Embase,CNKI,Wan-fang database,VIP database and CBM disc. The meta-analysis was performed to analyze the data. Results Twelve papers were obtained and were divided into two groups according to the purpose of the study. Group A included five articles about rs12979860 and spontaneous HBV clearance, and group B included nine articles about rs12979860 and interferon treatment response. The meta-analysis showed that there was no association between rs12979860 and spontaneous HBV clearance (OR=0.96,95% CI:0.76-1.20,P=0.700) and the response after interferon treatment for HBeAg-positive patients (OR=0.93, 95% CI:0.43-2.00,P=0.848), respectively. There was positive correlation between rs12979860 and the response after interferon treatment for HBe-negative patients, which manifested that the mutant genotype TC+TT significantly reduced the response after interferon treatment for HB e-negative patients. (total OR=0.47, 95% CI:0.25-0.87,P=0.016). Conclusions The mutant genotype TC+TT located on rs12979860 from gene IL-28B reduced the response after the interferon treatment for HBe-negative patients. |
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| Keywords: | Genes Hepatitis B, chronic Meta-analysis |
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