| 人乳头瘤病毒免疫逃避研究进展 |
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| 引用本文： | 田恬, 蔡爱杰, 黄冰雪, 戴江红. 人乳头瘤病毒免疫逃避研究进展[J]. 中华疾病控制杂志, 2016, 20(11): 1172-1175. doi: 10.16462/j.cnki.zhjbkz.2016.11.024 |
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| 作者姓名： | 田恬 蔡爱杰 黄冰雪 戴江红 |
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| 作者单位： | 新疆医科大学公共卫生学院流行病学与卫生统计学教研室, 新疆 乌鲁木齐 830011 |
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| 基金项目： | 国家自然科学基金(81560539) |
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| 摘 要： | 人乳头瘤病毒感染后可引起感染部位疣、癌等病变。绝大多数感染者会在4～20个月内清除体内的人乳头瘤病毒（human papillomavirus，HPV），少部分感染者体内将会有病毒持续存在并可能导致癌前损伤及癌变。机体不能成功清除HPV及感染的细胞，是宿主和病毒等多因素共同作用的结果，其中宿主免疫状态对于HPV转归结局的影响尤为重要。HPV逃避宿主免疫攻击引发的病毒清除障碍是HPV持续感染的关键。
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| 关 键 词： | 乳头状瘤病毒科 免疫系统 感染 |
| 收稿时间： | 2016-03-08 |
| 修稿时间： | 2016-05-16 |
Research progress of human papilloma virus immune evasion mechanisms |
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| TIAN Tian, CAI Ai-jie, HUANG Bing-xue, DAI Jiang-hong. Research progress of human papilloma virus immune evasion mechanisms[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(11): 1172-1175. doi: 10.16462/j.cnki.zhjbkz.2016.11.024 |
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| Authors: | TIAN Tian CAI Ai-jie HUANG Bing-xue DAI Jiang-hong |
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| Affiliation: | Department of Epidemiology and Health Statistics, School of Public Health, Xinjiang Medical University, Urumqi 830011, China |
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| Abstract: | Human papilloma virus infection can cause warts at infected site, cancer and other pathological changes. Most people can eliminate the virus in 4-20 months after exposure to HPV, however, the virus may continue existing in the body andlead to precancerous lesions and cancer in a small number of people. The discrepant outcomes of HPV infection depend on multiple factors, especially the interactions between host defense and virus, whereby an effective host immune response is particularly important.HPV escape from the host immune system is the key point of HPV persistence. In this review, we summarize relevant mechanisms of the evasion of the host immune system after HPV virus infection. |
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| Keywords: | Papillomaviridae Immune system Infection |
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