| 乌司他丁联合异甘草酸镁和还原型谷胱甘肽对肝癌患者肝部分切除术后肝功能的保护效果初步研究 |
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| 引用本文： | 邓清,张铁泉,乐问津,黄强,李宓,鲁号锋. 乌司他丁联合异甘草酸镁和还原型谷胱甘肽对肝癌患者肝部分切除术后肝功能的保护效果初步研究[J]. 实用肝脏病杂志, 2018, 21(3): 439-442. DOI: 10.3969/j.issn.1672-5069.2018.03.030 |
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| 作者姓名： | 邓清 张铁泉 乐问津 黄强 李宓 鲁号锋 |
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| 作者单位： | 434000 湖北省荆州市 长江大学第一附属医院/第一人民医院肝胆外科 |
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| 摘 要： | 目的 探讨乌司他丁联合异甘草酸镁和还原型谷胱甘肽对原发性肝癌（PLC）患者肝部分切除术后肝功能的保护效果。方法 2013年2月~2016年10月收治的78例PLC患者,行开腹或腔镜下肝部分切除术治疗,将术后患者分成两组,给予A组38例患者异甘草酸镁和还原型谷胱甘肽护肝、给予B组40例乌司他丁联合异甘草酸镁和还原型谷胱甘肽护肝治疗。采用ELISA法测定血清肿瘤坏死因子（TNF）-α、白介素（IL）-6和C反应蛋白（CRP）。结果 术后7 d和14 d,B组血清谷丙转氨酶（ALT）水平显著低于A组（P<0.05）; 术后7 d,B组血清CRP、TNF-α和IL-6水平分别为（17.2±2.7） mg/L、（2.7±0.6） pg/ml和（28.4±5.7） pg/ml,均显著低于A组[（19.8±3.2） mg/L、（3.5±0.7） pg/ml和（33.4±6.2） pg/ml,P<0.05],术后14 d,分别为（13.6±3.0） mg/L、（2.0±0.4） pg/ml和（20.5±4.7） pg/ml,也显著低于A组 [分别为（16.3±3.5） mg/L、（2.8±0.6） pg/ml和（24.6±4.9）pg/ml,P<0.05];术后,A组与B组隔下积液、胆漏发生和死亡发生率比较,差异无统计学意义（P>0.05）,但B组肝衰竭发生率为2.5%,显著低于A组的21.1%（P<0.05）。结论 乌司他丁联合异甘草酸镁和还原型谷胱甘肽可加强肝癌患者肝部分切除术后肝功能的保护作用,减轻机体炎症反应。
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| 关 键 词： | 原发性肝癌 肝部分切除术 乌司他丁 肝功能 |
| 收稿时间： | 2017-09-30 |
A preliminary study on the protective effect of combination of ulinastatin with magnesium isoglycyrrhizinate and reduced glutathione on liver functions in patients with primary liver cancer after partial hepatectomy |
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| Deng Qin,Zhang Tiequan,Yue Wenjin,et al. A preliminary study on the protective effect of combination of ulinastatin with magnesium isoglycyrrhizinate and reduced glutathione on liver functions in patients with primary liver cancer after partial hepatectomy[J]. Journal of Clinical Hepatology, 2018, 21(3): 439-442. DOI: 10.3969/j.issn.1672-5069.2018.03.030 |
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| Authors: | Deng Qin Zhang Tiequan Yue Wenjin et al |
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| Affiliation: | Department of Hepatobiliary Surgery,First People's Hospital,Affilated to Yangtze River University,Jingzhou 434000,Hubei Province,China |
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| Abstract: | Objective To investigate the protective effect of combination of ulinastatin with magnesium isoglycyrrhizinate and reduced glutathione on hepatic functions in patients with primary liver cancer after partial hepatectomy. Methods 78 patients with primary liver cancer were included in our hospital between February 2013 and October 2016,and they received partial hepatectomy. After operation,the patients were randomly divided into group B,receiving combination of ulinastatin,magnesium isoglycyrrhizinate and reduced glutathione,and group A,receiving magnesium isoglycyrrhizinate and reduced glutathione. Serum tumor necrosis factor （TNF）-α,interleukin （IL）-6 and C reactive protein（CRP） levels were detected by ELISA. Results There was no significant differences between the two groups as respect to the indexes of liver functions and serum inflammatory factors before operation（P>0.05）;serum alanine aminotransferase （ALT） level in group B seven days after operation were significantly lower than in group A （P<0.05）;at the end of seven days,serum CRP,TNF-α and IL-6 levels in group B were （17.2±2.7） mg/L,（2.7±0.6） pg/ml and （28.4±5.7） pg/ml,much lower than [（19.8±3.2） mg/L,（3.5±0.7） pg/ml and （33.4±6.2） pg/ml in group A,P<0.05],and at the end of 14 d,serum CRP,TNF-α and IL-6 levels in group B were（13.6±3.0） mg/L,（2.0±0.4） pg/ml and （20.5±4.7） pg/ml,much lower than[（16.3±3.5） mg/L,（2.8±0.6） pg/ml and（24.6±4.9）pg/ml in group A,P<0.05];there was no significant differences of the incidences of postoperative septal effusion,bile leakage and death between the two groups （P>0.05）,while the incidence of hepatic failure in group B was significantly lower than that in group A （2.5% vs. 21.1%,P<0.05）. Conclusion Combination of ulinastatin,magnesium isoglycyrrhizinate and reduced glutathionecan might enhance the protective effects on hepatic function in patients with primary liver cancer after partial hepatectomy. |
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| Keywords: | Hepatoma Partial hepatectomy Ulinastatin Liver functions |
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