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无机纳米声敏剂在肿瘤声动力治疗中的应用进展
引用本文:马静文, 孙晓莲. 无机纳米声敏剂在肿瘤声动力治疗中的应用进展[J]. 药学进展, 2018, 42(11): 824-830.
作者姓名:马静文  孙晓莲
作者单位:1.中国药科大学药分系 天然药物活性组分与药效国家重点实验室 药物质量与安全预警教育部重点实验室, 江苏 南京 210009
基金项目:国家自然科学基金(No. 51502251,No. 81571743);天然药物活性组分与药效国家重点实验室(中国药科大学)自主课题(No. SKLNMZZRC05)
摘    要:

肿瘤声动力治疗(SDT)是利用超声波将声能聚集于深部组织,并激活声敏药物产生抗肿瘤效应。SDT能够克服目前肿瘤治疗中诸如穿透深度有限等弊端。无机纳米声敏剂具有体内稳定性高、物理化学性质可控以及易于实现多功能化等优点,在肿瘤治疗方面具有广阔的应用前景。综述无机纳米声敏剂在SDT中的应用进展,并对其未来可能的研究方向进行展望。




关 键 词:超声  声动力治疗  活性氧自由基  无机纳米声敏剂

Nanosonotechnology: the next challenge in cancer sonodynamic therapy
MA Jingwen, SUN Xiaolian. Application of Inorganic Nanosonosensitizers in Sonodynamic Therapy for Tumor[J]. Progress in Pharmaceutical Sciences, 2018, 42(11): 824-830.
Authors:MA Jingwen  SUN Xiaolian
Affiliation:1.Department of Pharmaceutical Analysis, State Key Laboratory of Natural Medicines, Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China
Abstract:
Sonodynamic therapy (SDT) is a new strategy for tumor elimination that uses ultrasound to focus sound energy in deep tissues and activate sonosensitizer to produce anti-tumor effect. SDT could overcome some shortcomings of current tumor therapy, such as limited penetration depth. Inorganic nanomaterials-based sonosensitizers have attracted great attention because of their high in vivo stability, tunable physicochemical properties and ease of multifunctionalization. This review summarized recent studies on inorganic nanosonosensitizers in SDT and predicted their future trends of development.
Keywords:ultrasound  sonodynamic therapy  reactive oxygen species  inorganic nanosonosensitizer
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