| 植物化学物防治2型糖尿病并发认知功能障碍作用及机制的研究进展 |
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| 引用本文： | 石梦茜,赵海峰. 植物化学物防治2型糖尿病并发认知功能障碍作用及机制的研究进展[J]. 现代预防医学, 2021, 0(6): 1107-1110 |
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| 作者姓名： | 石梦茜 赵海峰 |
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| 作者单位： | 山西医科大学公共卫生学院营养与食品卫生学教研室,山西 太原 030001 |
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| 摘 要： | 目的 对植物化学物防治2型糖尿病并发认知功能障碍的作用及机制进行综述.方法 以2型糖尿病/Type2 diabetes mellitus/T2DM、胰岛素抵抗/insulin resistance、线粒体/mitochondria、内质网应激/endoplasmic reticulum stress和...
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| 关 键 词： | 植物化学物 2型糖尿病 认知功能障碍 胰岛素抵抗 炎症 |
Neuroprotective effect and mechanism of phytochemicals in type 2 diabetes mellitus-related cognitive dysfunction |
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| SHI Meng-qian,ZHAO Hai-feng. Neuroprotective effect and mechanism of phytochemicals in type 2 diabetes mellitus-related cognitive dysfunction[J]. Modern Preventive Medicine, 2021, 0(6): 1107-1110 |
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| Authors: | SHI Meng-qian ZHAO Hai-feng |
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| Affiliation: | Department of Nutrition and Food Hygiene, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, China |
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| Abstract: | To describe the benefits and mechanisms of phytochemicals on T2DM-induced cognitive dysfunction.Methods Literature search was conducted in CNKI, VIP, Wan-fang database, Pubmed, Science Direct and Springer from2010 to 2020 with “Type 2 diabetes mellitus/T2DM”, “insulin resistance”, “mitochondria”, “Endoplasmic reticulum stress”and “phytochemicals” as searching terms. Results The hyperglycemia and insulin resistance of T2DM can cause mitochondrial damage, endoplasmic reticulum stress, inflammation and cell apoptosis of neurons, which may lead to cognitive dysfunction. Various phytochemicals such as polyphenols and saponins exert cognitive protective effects by regulating the above-mentioned pathological changes. Conclusion Phytochemicals have a protective effect on cognitive impairment induced by T2DM animal model, providing a substantial laboratory basis for their effective prevention and treatment. However, the population evidence is not sufficient. |
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| Keywords: | Phytochemicals Type 2 diabetes mellitus Cognitive dysfunction Insulin resistance Inflammation |
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