| 非超重人群正常低密度脂蛋白胆固醇水平与非酒精性脂肪肝风险的前瞻性研究 |
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| 引用本文： | 董琦,阮海兰. 非超重人群正常低密度脂蛋白胆固醇水平与非酒精性脂肪肝风险的前瞻性研究[J]. 现代预防医学, 2021, 0(7): 1315-1319 |
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| 作者姓名： | 董琦 阮海兰 |
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| 作者单位： | 海南医学院第二附属医院消化内科,海口 570311 |
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| 摘 要： | 目的 探讨非超重人群正常低密度脂蛋白胆固醇(LDL-C)水平与非酒精性脂肪肝(NAFLD)的关系.方法 选取2015年1月至2017年6月在某医院进行健康体检的血清LDL-C水平在正常范围内的非超重人群4 822例为前瞻性研究随访队列,连续随访3年,以首次诊断为NAFLD为观察终点.根据彩超检查结果,将受试者分为NAF...
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| 关 键 词： | 脂肪肝 酒精性 低密度脂蛋白胆固醇 超重 影响因素分析 |
Prospective study on the relationship between normal low-density lipoprotein cholesterol levels and non-alcoholic fatty liver disease in the non-overweight population |
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| DONG Qi,RUAN Hai-lan. Prospective study on the relationship between normal low-density lipoprotein cholesterol levels and non-alcoholic fatty liver disease in the non-overweight population[J]. Modern Preventive Medicine, 2021, 0(7): 1315-1319 |
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| Authors: | DONG Qi RUAN Hai-lan |
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| Affiliation: | Department of Digestive Medical,the Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, China |
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| Abstract: | To investigate the relationship between normal low-density lipoprotein cholesterol(LDL-C) levels and non-alcoholic fatty liver disease(NAFLD) in the non-overweight population.Methods 4 822 non-overweight physical examinees with serum LDL-C levels within the normal range in a certain hospital from January 2015 to June 2017 were enrolled as the prospective study follow-up cohort.Follow-up was undertaken consecutive for 3 years, and observation ended at the first diagnosis of NAFLD.Based on color Doppler ultrasound examination of the liver, subjects with NAFLD were assigned to the NAFLD group(n=688), and other subjects without NAFLD were assigned to the non-NAFLD group(n=4 134). According to the quartiles of serum LDL-C level, subjects were divided into quartiles 1, 2, 3, 4 groups(Ql group, serum LDL-C<1.9 mmol/L, n=1 225; Q2 group, 1.9 mmol/L≤serum LDL-C<2.2 mmol/L, n=1 224; Q3 group, 2.2 mmol/L≤serum LDL-C<2.6 mmol/L, n=1 193; Q4 group, serum LDL-C≥2.6 mmol/L, n=1 180). Clinical data of all subjects were collected. Pearman correlation analysis, Kaplan-Meier survival analysis, multivariate Cox risk proportional regression model analysis were used to explore the relationship between normal LDL-C levels and NAFLD in the non-overweight population.Results The accumulated morbidity of NAFLD increased with the elevation of serum LDL-C levels within the normal range in non-overweight population(P<0.001). Kaplan-Meier survival analysis shows that Q1 group, Q2 group, Q3 group and Q4 group were significantly different in accumulated morbidity(X2=85.629, P<0.001). Taking Q1 group as reference group, multivariate Cox risk proportional regression model analysis showed that after adjusting for age and other metabolism-related indicators, Q3 group[HR=1.426, 95%CI(1.062, 1.927)] and Q4 group[HR=1.917, 95%CI(1.348, 2.786)]were the influencing factors of NAFLD(P<0.05). Conclusion In non-overweight population with serum LDL-C levels within the normal range, higher serum LDL-C levels is associated with higher risk of NAFLD. |
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| Keywords: | Fatty liver Alcoholic Low-density lipoprotein cholesterol Overweigh Root cause analysis |
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