| 血管生成素-2和内皮抑素在子宫内膜异位症中的高表达 |
| |
| 引用本文： | 范俊,董文韬,孙宝治,李晓林,刘波,王纯. 血管生成素-2和内皮抑素在子宫内膜异位症中的高表达[J]. 基础医学与临床, 2009, 29(11): 1203-1206 |
| |
| 作者姓名： | 范俊 董文韬 孙宝治 李晓林 刘波 王纯 |
| |
| 作者单位： | 山东省青岛市市立医院妇科,山东,青岛,266071;山东省莱西市人民医院妇产科,山东,莱西,266600 |
| |
| 摘 要： | 目的 探讨血管生成素-2（ANG-2）和内皮抑素（ENS）在子宫内膜异位症发生发展中的作用。方法 卵巢子宫内膜异位症病人25例，24例无内膜病变者为对照组。留取子宫内膜，用免疫组化染色法检测ANG -2和ENS在子宫内膜中的表达，用酶联免疫吸附测定法检测腹腔液中ANG -2和ENS的蛋白含量。结果ANG -2在位子宫内膜组织中的阳性表达率显著高于异位内膜和对照组，异位内膜中阳性表达率显著高于对照组；ENS在异位内膜组织中的表达明显高于在位内膜和对照组，在位内膜明显高于对照组；ANG-2及ENS表达强度在子宫内膜异位症Ⅰ、Ⅱ期与Ⅲ、Ⅳ比较无显著差异。异位组腹腔液的ANG-2、ENS含量和ANG-2/ENS 比值均显著高于对照组。结论ANG-2和ENS在子宫内膜异位症血管生成中起到重要的作用，参与调节异位病灶的发生和进展。
|
| 关 键 词： | 血管生成素2 内皮抑素 子宫内膜异位症 腹腔液 |
| 收稿时间： | 2008-08-06 |
| 修稿时间： | 2008-12-26 |
High expression of angiopoietin-2 and endostatin in endometriosis |
| |
| FAN Jun,DONG Wen-tao,SUN Bao-zhi,LI Xiao-lin,LIU Bo,WANG Chun. High expression of angiopoietin-2 and endostatin in endometriosis[J]. Basic Medical Sciences and Clinics, 2009, 29(11): 1203-1206 |
| |
| Authors: | FAN Jun DONG Wen-tao SUN Bao-zhi LI Xiao-lin LIU Bo WANG Chun |
| |
| Abstract: | Objective To explore the effect of Angiopoietin-2(ANG-2) and Endostatin (ENS) in patho genesis and development of endometriosis. Methods Twenty-five endometriosis cases and 24 controls were enrolled. ANG-2 and ENS in endometrium were detected by Immunohistochemistry. The concentrations of ANG-2 and ENS in peri-toneal fluid were measured with enzyme linked immunoabsorbant assay. Results In the EMs group, ANG-2 positive rate in eutopic endometrium was significantly higher than that of ectopic endometrium. The ANG-2 positive rate in ectopic endometrium was significantly higher than that of control group; in EMs group, the ENS positive rate in ec-topic endometrium was significantly higher than that in eutopic endometrium. The ENS positive rate in eutopic endo-metrium was significantly higher than that in control group. There was no significant difference of ANG-2 or ENS between stage Ⅰ～Ⅱand stage Ⅲ～Ⅳ. In peritoneal fluid, ANG-2 and ENS concentration and ratio of ANG-2/ ENS in endometriosis were significantly higher than that in controls. Conclusion The effect of angiopoietin-2 and endostatin in angiogenesis of endometriosis are important play a role in pathogenesis and development of the endo-metriosis. |
| |
| Keywords: | angiopoietin-2 endostatin endometriosis peritoneal fluid |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《基础医学与临床》浏览原始摘要信息 |
|
点击此处可从《基础医学与临床》下载全文 |
|
