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A BALB/c congenic strain of mice that carries a genetic locus (Ityr) controlling resistance to intracellular parasites. |
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| Authors: | M Potter A D O''''Brien E Skamene P Gros A Forget P A Kongshavn J S Wax |
| Abstract: | BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b congenic mice were developed by introgressively backcrossing the Idh-1b and Pep-3b markers of DBA/2 mice onto the BALB/c pi mice. This introduced a 30-centimorgan chromosome 1 segment of DBA/2 chromatin that contained the Ityr gene. BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b mice were resistant to in vivo infections by Salmonella typhimurium, Mycobacterium bovis, and Leishmania donovani. |
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