The T11(3) epitope of the CD2 molecule, sheep erythrocytes, and the alternative T-cell activation pathway. |
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| Authors: | H S Warren V McPhun A Bezos C R Parish |
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| Affiliation: | Cancer Research Unit, Woden Valley Hospital, Australian Capital Territory. |
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| Abstract: | In this study, results are presented showing that the T11(3) epitope of the CD2 molecule is expressed on unfractionated peripheral blood mononuclear cells, resting T cells and activated T cells. T11(3) is not therefore, an activation-specific CD2 epitope. Sheep erythrocytes (SRC) which present a cell-surface ligand for CD2 could not effectively replace anti-T11(2) in initiating proliferation of resting T cells, stimulated by anti-T11(3). SRC with either of these anti-CD2 monoclonal antibodies did activate resting T cells, but proliferation required the presence of added IL-2. |
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