| 动态监测D-二聚体在肿瘤患者导管相关性血栓的临床意义 |
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| 引用本文： | 杨敏,谢俊英,谭培昭,吴晓明,于雷. 动态监测D-二聚体在肿瘤患者导管相关性血栓的临床意义[J]. 实用肿瘤学杂志, 2019, 33(5): 425-430. DOI: 10.11904/j.issn.1002-3070.2019.05.008 |
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| 作者姓名： | 杨敏 谢俊英 谭培昭 吴晓明 于雷 |
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| 作者单位： | 1.国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院综合科(北京 100021); 2.北京市朝阳区桓兴肿瘤医院静脉置管中心; 3.北京市朝阳区桓兴肿瘤医院综合科 |
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| 摘 要： | 目的 探讨D-二聚体水平与肿瘤患者导管相关性血栓(Catheter related thrombosis,CRT)发生的相关性。方法 对100例住院的深静脉置管肿瘤患者进行前瞻性研究,动态监测血浆D-二聚体以及静脉多普勒超声检查,观察CRT的发生率、发生时间及血栓类型等。结果 CRT的发生率为12.6%,其中无症状血栓占83.3%。58.3%的血栓发生在置管后2周内,91.7%发生在置管后的置管后4周内。置管后2周血栓组D-二聚体水平显著高于非血栓组(P=0.013)。结论 肿瘤患者CRT大部分形成于深静脉置管后4周内,其中无症状性血栓的比例高,动态监测D-二聚体可能有助于其早期诊断。
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| 关 键 词： | D-二聚体 肿瘤 导管相关性血栓 |
Clinical significance of dynamic monitoring of D-dimer in catheter related thrombosis of cancer patients |
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| YANG Min,XIE Junying,TAN Peizhao,WU Xiaoming,YU Lei. Clinical significance of dynamic monitoring of D-dimer in catheter related thrombosis of cancer patients[J]. Journal of Practical Oncology, 2019, 33(5): 425-430. DOI: 10.11904/j.issn.1002-3070.2019.05.008 |
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| Authors: | YANG Min XIE Junying TAN Peizhao WU Xiaoming YU Lei |
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| Affiliation: | 1.Comprehensive Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China; 2.Catheter center,Cancer Hospital of Huanxing Chaoyang District Beijing; 3.General Department,Cancer Hospital of Huanxing Chaoyang District Beijing |
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| Abstract: | Objective The objective of this study was to investigate the correlation between D-dimer levels and the occurrence of catheter related thrombosis(CRT)in tumor patients.Methods A prospective study was performed on 100 cancer patients with deep venous catheterization.The plasma D-dimer and intravenous Doppler ultrasonography were used to observe the incidence,time and thrombus type of CRT.Results The incidence of CRT was 12.6%,and asymptomatic thrombosis accounted for 83.3%.58.3% of the thrombosis occurred within 2 weeks after catheterization,and 91.7% occurred within 4 weeks after catheterization.After 2 weeks of catheterization,the level of D-dimer in the thrombosis group was significantly higher than that in the non-thrombosis group(P=0.013).Conclusion Most of the CRT in tumor patients is formed within 4 weeks after deep venous catheterization.The proportion of asymptomatic thrombus is high,and dynamic monitoring of D-dimer may be helpful for early diagnosis. |
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| Keywords: | D-dimer Cancer Catheter related thrombosis |
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