| 基于“脑-肠”轴的肠道菌群影响抑郁症研究进展 |
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| 引用本文： | 陶伟伟,董宇,刘立,肖东,吴浩然,吴颢昕,陈刚,狄留庆,王汉卿. 基于“脑-肠”轴的肠道菌群影响抑郁症研究进展[J]. 南京中医药大学学报, 2019, 35(2): 234-240 |
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| 作者姓名： | 陶伟伟 董宇 刘立 肖东 吴浩然 吴颢昕 陈刚 狄留庆 王汉卿 |
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| 作者单位： | 1.南京中医药大学基础医学院中医脑病学重点实验室，江苏 南京 210023 |
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| 摘 要： | 近年来，随着对肠道菌群调控作用研究的不断深入，用来描述胃肠道微生物群与宿主之间复杂网络关系的“脑-肠”轴应运而生。它是基于肠道菌群的存在于哺乳动物体内的一种双向信息调节通路，在人体健康和疾病进程中发挥着重要作用。抑郁症是区别于简单情绪障碍的一种持续时间长并且反复发作的慢性精神疾病。有研究表明，肠道菌群能够通过“脑-肠”轴对宿主的应激反应、焦虑、抑郁和认知功能产生重要影响。该文基于肠道菌群综述了抑郁症的研究现状和机制，旨在为抑郁症的治疗提供依据和参考。
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| 关 键 词： | 肠道菌群 “脑-肠”轴 抑郁症 作用机制 |
Research Progress on the Effect of Intestinal Flora on Depression Based on "Brain-Gut" Axis |
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| TAO Wei-wei,DONG Yu,LIU Li,XIAO Dong,WU Hao-ran,WU Hao-xing,CHEN Gang,DI Liu-qing,WANG Han-qing. Research Progress on the Effect of Intestinal Flora on Depression Based on "Brain-Gut" Axis[J]. Journal of Nanjing University of Traditional Chinese Medicine(Natural Science), 2019, 35(2): 234-240 |
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| Authors: | TAO Wei-wei DONG Yu LIU Li XIAO Dong WU Hao-ran WU Hao-xing CHEN Gang DI Liu-qing WANG Han-qing |
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| Affiliation: | 1.Key Laboratory for Encephalopathy of Chinese Medicine, School of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China2.School of Pharmacy, Nanjingl University of Chinese Medicine, Nanjing, 210023, China3.School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China |
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| Abstract: | In recent years， with the deepening of the research on the regulation of intestinal flora， the "brain-gut" axis， which is used to describe the complex network relationship between gastrointestinal microflora and their hosts. It is a bidirectional information regulation pathway based on the presence of intestinal flora in mammals and plays an important role in human health and disease process. Depression is a long and recurring chronic mental illness that differs from simple mood disorders. Studies have shown that intestinal flora can significantly influence host stress response， anxiety， depression and cognitive function through the brain-gut axis. Based on the intestinal flora， this paper reviewed the research status and mechanism of depression， aiming to provide basis and reference for the treatment of depression. |
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| Keywords: | intestinal flora brain-gut axis depression mechanism |
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