|
|||||
|
|
| 非桥粒芯糖蛋白抗体在寻常型天疱疮中的作用机制 | |
| 引用本文： | 谢志敏,沈旭成,戴向农,李青青,叶兴东. 非桥粒芯糖蛋白抗体在寻常型天疱疮中的作用机制[J]. 中国麻风皮肤病杂志, 2021, 37(5): 324-327. DOI: 10.12144/zgmfskin202105324 |
| 作者姓名： | 谢志敏 沈旭成 戴向农 李青青 叶兴东 |
| 作者单位： | 1广州市皮肤病防治所皮肤科，广州，510095；2广州医科大学皮肤病研究所皮肤科，广州，510095 |
| 摘 要： | 既往发现寻常型天疱疮(pemphigus vulgaris,PV)发病机制与桥粒芯糖蛋白1(desmoglein,Dsg1)和Dsg3抗体有关,目前在PV患者中发现大量非Dsg自身免疫性抗体,包括桥粒胶蛋白1(desmocollin,Dsc1)和Dsc3、斑菲素蛋白1(plakophilin,PKP1)和PKP3、斑珠... |
| 关 键 词： | 寻常型天疱疮 桥粒胶蛋白 斑菲素蛋白 乙酰胆碱受体 甲状腺过氧化物酶 |
Update of non-desmoglein IgG autoantibodies in the pathogenesis of pemphigus vulgaris |
|
| XIE Zhimin,SHEN Xuchen,DAI Xiangnong,LI Qingqing,YE Xingdong. Update of non-desmoglein IgG autoantibodies in the pathogenesis of pemphigus vulgaris[J]. China Journal of Leprosy and Skin Diseases, 2021, 37(5): 324-327. DOI: 10.12144/zgmfskin202105324 | |
| Authors: | XIE Zhimin SHEN Xuchen DAI Xiangnong LI Qingqing YE Xingdong |
| Affiliation: | 1 Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou 510095, China; 2 Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, China |
| Abstract: | The the pathogenesis of pemphigus vulgaris (PV) was associated with autoantibodies against desmosomal cadherin, desmoglein1 (Dsg1) and Dsg3 in previous studies, and now many non-Dsg autoantibodies were reported including desmocollin (Dsc) 1 and Dsc3, plakophilin (PKP) 1 and PKP3, plakoglobin (PG), desmoplakin (DP), acetylcholine receptor (AChR), secretory pathway Ca2+/Mn2+-ATPase isoform 1 (SPCA1), thyroid peroxidase (TPO) and mitochondrial protein. The non-Dsg autoantibodies associated with pathogenesis of PV were reviewed in this paper. |
| Keywords: | pemphigus vulgaris desmocollin plakophilin acetylcholine receptor thyroid peroxidase |
| 本文献已被 CNKI 等数据库收录！ | |
| 点击此处可从《中国麻风皮肤病杂志》浏览原始摘要信息 | |
| 点击此处可从《中国麻风皮肤病杂志》下载免费的PDF全文 | |