Eliminated chromatin of Ascaris contains a gene that encodes a putative ribosomal protein. |
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| Authors: | A Etter M Aboutanos H Tobler F Müller |
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| Affiliation: | Institute of Zoology, University of Fribourg, Switzerland. |
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| Abstract: | Chromatin diminution in the nematodes Parascaris equorum and Ascaris lumbricoides leads to the formation of somatic cells that contain less DNA than the germ-line cells. We present molecular evidence for the coding potential of germ-line-specific DNA. We report on a cDNA clone that codes for a putative ribosomal protein (ALEP-1, for A. lumbricoides eliminated protein 1). That the corresponding gene is located in the eliminated portion of the genome indicates a difference in germ-line and somatic ribosomes of A. lumbricoides and P. equorum. Elimination of the ALEP-1 gene from all somatic cells in its fully active state may represent an alternative way to gene regulation. |
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