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| NSCLC细胞周期素D1和p27异常表达与化疗敏感性及预后的相关性研究 | |
| 引用本文： | 李蓓,张磊,王卉,郝静,扈东艳,李明,王秀问. NSCLC细胞周期素D1和p27异常表达与化疗敏感性及预后的相关性研究[J]. 山东大学学报(医学版), 2006, 44(9): 963-965 |
| 作者姓名： | 李蓓 张磊 王卉 郝静 扈东艳 李明 王秀问 |
| 作者单位： | 1 山东大学齐鲁医院化疗科， 山东 济南 250012； 2山东大学第二医院泌尿外科，山东 济南 250033；3 山东省肿瘤医院放疗科，山东 济南 250117 |
| 摘 要： | 目的：研究细胞周期素D1(cyclin D1)和p27在非小细胞肺癌（NSCLC）中的表达与化疗敏感性及预后的关系，评价其表达在NSCLC中的临床价值。方法：应用S P方法检测了37例原发性NSCLC石蜡切片中cyclin D1和p27的表达。结果：37例NSCLC患者中，cyclin D1阳性表达者21例（56.76％），其表达和NSCLC患者的化疗疗效和预后显著相关(P＜0.05)。p27阳性表达率为32.43%(12/37)，其表达与NSCLC患者的化疗疗效无相关性(P＞0.05)，与患者的生存期显著相关(P＜0.05)。多因素分析表明，cyclin D1可作为NSCLC的独立预后因素。结论：NSCLC中cyclin D1的表达可作为预测化疗疗效和预后的指标；p27的表达可作为NSCLC的预后因素。 |
| 关 键 词： | 肺肿瘤 化学疗法 细胞周期素 预后 |
| 文章编号： | 1671-7554（2006）09-0963-04 |
| 收稿时间： | 2006-03-20 |
| 修稿时间： | 2006-03-20 |
Correlation between chemosensitivity and prognosis andabnormal expression of cyclin D1 and p27 in |
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| LI Bei,ZHANG Lei,WANG Hui,HAO Jing,HU Dong-yan,LI Ming,WANG Xiu-wen. Correlation between chemosensitivity and prognosis andabnormal expression of cyclin D1 and p27 in[J]. Journal of Shandong University:Health Sciences, 2006, 44(9): 963-965 | |
| Authors: | LI Bei ZHANG Lei WANG Hui HAO Jing HU Dong-yan LI Ming WANG Xiu-wen |
| Affiliation: | 1. Department of Chemotherapy, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;2. Department of Urology, Second Hospital of Shandong University, Jinan 250033, Shandong, China; |
| Abstract: | Objective:To prognose the chemosensitivity and the survival in terms of the expression levels of cyclin D1 and p27 protein in non-small cell lung cancer(NSCLC).Method: Enhanced immunohistochemical staining(SP) technique was used to detect the expression of cyclin D1 and p27 protein in 37 cases of primary NSCLC specimens paraffin-embedded.Results:Of the 37 NSCLC cases,positive cyclin D1 was found in 21(56.76%),and there were significant correlation between response to chemotherapy,survival and the expression of cyclin D1(P<0.05). The positive expression rate of p27 protein was 32.43%(12/37),and there were no significant relationship between the expression of p27 and response to chemotherapy(P>0.05).The expression of p27 was significantly associated with the survival of NSCLC.Multivariate analysis showed that cyclin D1 was a good prognostic factor in NSCLC.Conclusion: Expression of cyclin D1 may be a good prognostic factor for chemosensitivity and survival in NSCLC.Furthermore,the expression of p27 may play a prognostic role in NSCLC. |
| Keywords: | Lung carcinoma Chemotherapy Cyclins Prognosis |
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