Comparison of gemcitabine plus cisplatin versus capecitabine plus cisplatin as first‐line chemotherapy for advanced biliary tract cancer |
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| Authors: | Kwonoh Park Kyu‐pyo Kim Seongjoon Park Heung‐Moon Chang |
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| Affiliation: | 1. Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea;2. Department of Internal Medicine, Medical Oncology and Hematology, Pusan National University Yangsan Hospital, Korea |
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| Abstract: | Aim : It remains unclear whether capecitabine combined with cisplatin would show similar effects compared with standard therapy using gemcitabine and cisplatin in advanced biliary tract cancer (BTC). Methods : Patients with advanced BTC who were treated with first‐line chemotherapy at Asan Medical Center were retrospectively analyzed. All patients received either cisplatin followed by gemcitabine on days 1 and 8 every 3 weeks (GP group), or capecitabine on days 1–14 with cisplatin on day 1 every 3 weeks (XP group). Results : Of the 134 patients who met the inclusion criteria, 78 received XP and 56 were treated with GP. After a median follow‐up of 26.2 months, the progression‐free survival was 5.7 months for XP versus 4.1 months for GP (hazard ratio [HR] = 0.81, P = 0.31). The overall survival (OS) was 11.0 months for XP versus 9.8 months for GP (HR = 0.84, P = 0.36). In the multivariate analysis, there were no significant differences in PFS and OS between the two groups. Conclusion : XP seems to be as effective as GP in patients with advanced BTC. The XP regimen is feasible and might offer increased convenience regarding the schedule of drug administration. |
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| Keywords: | biliary tract cancer capecitabine cisplatin gemcitabine |
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