| 氯化汞对培养乳鼠心肌细胞和家兔窦房结电活动的影响 |
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| 引用本文： | 马 欣 荆伟庆 赵松珍. 氯化汞对培养乳鼠心肌细胞和家兔窦房结电活动的影响[J]. 中国药理学与毒理学杂志, 1997, 11(3): 237-238 |
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| 作者姓名： | 马 欣 荆伟庆 赵松珍 |
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| 作者单位： | 西安医科大学药理学教研室 |
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| 摘 要： | 氯化汞对培养乳鼠心肌细胞和家兔窦房结电活动的影响１马欣荆伟庆赵松珍２（西安医科大学药理学教研室，２第一附属医院神经科，西安７１００６１）汞是一种微量元素，长期大剂量接触可产生心脏毒性作用，如引起不同类型的心律失常［１］．但是，汞对心血管系统的毒性机理...
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| 关 键 词： | 氯化汞；心肌；细胞 培养的；窦房结；动作电位 |
| 收稿时间： | 1996-04-29 |
Effects of mercuric chloride on electric activity of cultured neonatal rat myocardial cells and rabbit sinoatrial node |
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| MA Xin, JING Wei-Qing, ZHAO Song-Zhen. Effects of mercuric chloride on electric activity of cultured neonatal rat myocardial cells and rabbit sinoatrial node[J]. Chinese Journal of Pharmacology and Toxicology, 1997, 11(3): 237-238 |
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| Authors: | MA Xin JING Wei-Qing ZHAO Song-Zhen |
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| Affiliation: | MA Xin, JING Wei-Qing, ZHAO Song-Zhen2 |
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| Abstract: | Glass microelectrode technique was used to investigate the effects of mercuric chloride (HgCl2) on the electrophysiological action of cultured neonatal rat myocardial cells and rabbit sinoatrial node. HgCl25 μmol·L-1 decreased the amplitude and the Vmax of action potential (P<0.05), shortened the duration of action potentials at 50% and 100% of repolarization of primary cultured rat myocardial cells. HgCl2 20 μmol·L-1 decreased rabbit sinus rate and Vmax of phase 0 of action potentials of sinoatrial node was decreased from 3.2±0.9 V·s-1 to 1.9±0.6 V·s-1, but the sinus cycle length increased. The action potential phase 4 depolarization of the isolated rabbits sinoatrial node slowed from 61±4 mV·s-1 to 22±4 mV·s-1. The study suggests that HgCl2 induced arrythmias may be related to the blockade effect on Ca2+ channel of myocardium cells. |
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| Keywords: | mercuric chloride myocardium cells cultured sinoatrial node action potentials |
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