| 3D打印多孔钽种植体对骨整合影响的实验研究 |
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| 引用本文： | 苏可欣,季平,王涵,李林林,苏雷震,王超. 3D打印多孔钽种植体对骨整合影响的实验研究[J]. 华西口腔医学杂志, 2018, 36(3): 291-295. DOI: 10.7518/hxkq.2018.03.012 |
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| 作者姓名： | 苏可欣 季平 王涵 李林林 苏雷震 王超 |
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| 作者单位： | 重庆医科大学附属口腔医院口腔颌面外科,口腔疾病与生物医学重庆市重点实验室,重庆市高校市级口腔生物医学工程重点实验室,重庆 401147 |
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| 基金项目： | 国家自然科学基金青年科学基金（11402042）;重庆市基础与前沿研究计划（CSTC2015jcyjA10027）;重庆市科委社会民生一般项目（CSTC2015shmszx10008）;重庆市卫生计生委面上项目（2017MSXMD73）;2016年重庆高校创新团队建设计划（CX-TDG201602006） |
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| 摘 要： | 目的 研究多孔钽及多孔钛种植体对骨整合的影响。方法 通过计算机辅助设计方法建模,采用3D打印技术制备两种微孔参数相同的多孔材料种植体：多孔钽及多孔钛。在24只新西兰大白兔双侧股骨外踝处建立骨缺损模型,每只动物左右侧缺损随机分组,分别用多孔钽（实验组）和多孔钛（对照组）种植体进行修复。种植体植入后2、4、8周取材,进行大体观察和亚甲基蓝-酸性品红染色,观测种植体和骨界面的骨整合情况,采用推出实验测试种植体-骨界面结合强度。 结果 术后2、4、8周,两组材料界面的新生骨组织逐渐增加,出现新生骨小梁并向材料孔隙内生长;两组的成骨情况及种植体-骨组织界面结合强度的差异无统计学意义（P>0.05）。结论 3D打印的多孔钽能与骨组织形成早期的生物结合,具有与多孔钛相当的骨整合能力。
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| 关 键 词： | 多孔钽 3D打印 骨整合 种植修复 |
| 收稿时间： | 2017-10-15 |
| 修稿时间： | 2018-01-12 |
In vivo study of 3D printed porous tantalum implant on osseointegration |
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| Kexin Su,Ping Ji,Han Wang,Linlin Li,Leizhen Su,Chao Wang. In vivo study of 3D printed porous tantalum implant on osseointegration[J]. West China journal of stomatology, 2018, 36(3): 291-295. DOI: 10.7518/hxkq.2018.03.012 |
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| Authors: | Kexin Su Ping Ji Han Wang Linlin Li Leizhen Su Chao Wang |
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| Affiliation: | Dept. of Oral and Maxillofacial Surgery, The Affiliated Stomatology Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, China |
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| Abstract: | Objective This work aims to investigate the effect of porous tantalum and porous titanium on osseointegration. Methods Two kinds of porous materials with same microporous parameters, namely, porous tantalum and porous titanium, were fabricated by computer-aided design (CAD) modeling and 3D printing technology. A defect model was established in 24 New Zealand white rabbits in the bilateral femoral lateral malleolus at the left and right side of each animal. Then, animals were randomly divided into two groups, and bone defects were repaired by porous tantalum and porous titanium (experimental and control groups, respectively). Animals were sacrificed at two, four, and eight weeks after implantation. Gross observation and methylene blue-acid fuchsin staining were used to observe osseointegration of the implant and bone interface, and the osseointegration strength of implant bone interface was tested by push-out test. Results At two, four, and eight weeks after operation, the new bone tissue in the two groups increased gradually, and new bone trabecula appeared and grew into the pores of the materials. No significant difference (P>0.05) in osteo-genesis and the strength of implant bone tissue interface between the two groups was observed. Conclusion 3D printed porous tantalum implants, which exhibit comparable osseointegration capabilities to porous titanium implants, can form an early biological combination with bone tissue. |
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| Keywords: | porous tantalum 3D printing osseoin-tegration implant repair |
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