| 缺血性脑血管病患者同型半胱氨酸和基质金属蛋白酶-9与颈动脉粥样硬化的关系 |
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| 引用本文： | 余传庆,张梅,薛敏. 缺血性脑血管病患者同型半胱氨酸和基质金属蛋白酶-9与颈动脉粥样硬化的关系[J]. 蚌埠医学院学报, 2011, 36(8): 831-834,836 |
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| 作者姓名： | 余传庆 张梅 薛敏 |
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| 作者单位： | 安徽省淮南市第一人民医院神经内科, 232007 |
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| 基金项目： | 安徽省2008年度科研计划资助项目 |
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| 摘 要： | 目的: 探讨缺血性脑血管病(ICVD)患者同型半胱氨酸(Hcy)和基质金属蛋白酶-9(MMP-9)与颈动脉粥样硬化(CAS)斑块及其硬化程度的关系。方法: 240例确诊的ICVD患者(ICVD组,又分为有CAS斑块组123例和无CAS斑块组117例)和236例非脑血管病患者(对照组),均接受颈动脉超声检查,检测颈动脉内膜中层厚度(IMT)状况,并对血浆Hcy和MMP-9水平与CAS的斑块及其硬化程度分型进行相关性分析。结果: ICVD患者Hcy和MMP-9水平均明显高于对照组(P < 0.01),ICVD患者斑块组Hcy和MMP-9水平均明显高于无斑块组(P < 0.01)。ICVD组颈动脉IMT与Hcy和MMP-9水平呈正相关关系(P < 0.05);ICVD组颈动脉硬化程度与Hcy及MMP-9水平呈正相关关系(P < 0.05);ICVD组血浆Hcy与MMP-9水平呈正相关关系(P < 0.01)。高龄、高血压、高脂血症、糖尿病、吸烟、饮酒及冠心病对ICVD动脉粥样硬化斑块的形成影响较大。结论: ICVD患者中,CAS斑块形成可能与血浆Hcy和MMP-9升高有关,CAS程度愈高,其相关性愈大,ICVD患者Hcy和MMP-9水平可以反映颈动脉斑块的性质和稳定性,是临床了解ICVD严重程度的重要指标。
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| 关 键 词： | 脑血管意外 同型半胱氨酸 基质金属蛋白酶-9 颈动脉粥样硬化 |
| 收稿时间： | 2010-09-26 |
Relationship between the levels of plasma homocysteine,matrix metalloproteinase-9 and carotid atherosclerosis in patients with ischemic cerebrovascular disease |
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| YU Chuan-qing,ZHANG Mei,XUE Min. Relationship between the levels of plasma homocysteine,matrix metalloproteinase-9 and carotid atherosclerosis in patients with ischemic cerebrovascular disease[J]. Journal of Bengbu Medical College, 2011, 36(8): 831-834,836 |
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| Authors: | YU Chuan-qing ZHANG Mei XUE Min |
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| Affiliation: | Department of Neurology, Huainan First People's Hospital, Huainan Anhui 232007, China |
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| Abstract: | Objective：To investigate the relationship between the levels of plasma homocysteine（Hcy）,matrix metalloproteinase-9（MMP-9） and carotid atherosclerosis（CAS） in patients with ischemic cerebrovascular disease（IVCD）.Methods：Two hundred and forty patients with IVCD（IVCD group） and 236 patients without cerebrovascular diseases（control group） received carotid ultrasonograph to detect the intima-media thickness（IMT） of the carotid artery.The correlation analysis was made between the levels of Hcy,MMP-9 and CAS plaque and its degree.Results：The levels of Hcy and MMP-9 in IVCD group were significantly higher than those in control group（P〈0.01）;the levels of Hcy and MMP-9 in IVCD group with carotid atherosclerotic plaque were significantly higher than that in control group（P〈0.01）;the IMT was positively correlated with the level of Hcy and MMP-9 in IVCD group（P〈0.05）;the degree of CAS was positively correlated with the level of Hcy and MMP-9 in IVCD group（P〈0.05）;the level of Hcy was positively correlated with that of MMP-9 in IVCD group（P〈0.01）.Age,hypertension,hyperlipidemia,diabetes,smoke,drink and coronary artery disease were important risk factors for formation of CAS plaque.Conclusions：The formation of CAS plaque may be closely associated with the level of Hcy and MMP-9 in patients with IVCD.There is higher degree of CAS,the more correlation between CAS and Hcy or MMP-9.The levels of Hcy and MMP-9 in patients with IVCD may reflect the character and stability of carotid artery plaque,and they can be important indicators about the severity of IVCD for clinical practice. |
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| Keywords: | ischemic cerebrovascular disease homocysteine matrix metalloproteinase-9 carotid atherosclerosis |
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