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Value of flow cytometric analysis of peripheral blood samples in children diagnosed with acute lymphoblastic leukemia |
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| Authors: | Grace Lam Angela Punnett Derek Stephens Lillian Sung Johann Hitzler |
| Affiliation: | 1. Division of Hematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada;2. Clinical Research Services, The Hospital for Sick Children, Toronto, Ontario, Canada;3. Child Health Evaluative Sciences, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada;4. Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, CanadaMohamed Abdelhaleem and Johann Hitzler are co‐senior authors. |
| Abstract: | Diagnostic procedures in children with acute lymphoblastic leukemia (ALL) are typically performed under general anesthesia. Anticipation of the diagnosis based on findings in peripheral blood allows scheduling of the first dose of intrathecal chemotherapy and diagnostic bone marrow (BM) aspirate during a single anesthetic. We retrospectively compared paired results of peripheral blood (PB) flow cytometric analysis and BM evaluation in 383 children with ALL diagnosed consecutively at a single center and found very high concordance of results between both tests. We conclude that PB flow cytometry may help streamline planning of procedure‐related anesthetics during diagnosis and early treatment of childhood ALL. |
| Keywords: | acute lymphoblastic leukemia diagnosis flow cytometry pediatric peripheral blood |