Rv2686c-Rv2687c-Rv2688c, an ABC fluoroquinolone efflux pump in Mycobacterium tuberculosis |
| |
| Authors: | Pasca Maria Rosalia Guglierame Paola Arcesi Fabio Bellinzoni Marco De Rossi Edda Riccardi Giovanna |
| |
| Affiliation: | Department of Genetics and Microbiology, University of Pavia, 27100 Pavia, Italy. |
| |
| Abstract: | The Mycobacterium tuberculosis Rv2686c-Rv2687c-Rv2688c operon, encoding an ABC transporter, conferred resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin, and sparfloxacin to Mycobacterium smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine, carbonyl cyanide m-chlorophenylhydrazone, and verapamil. Energy-dependent efflux of ciprofloxacin from M. smegmatis cells containing the Rv2686c-Rv2687c-Rv2688c operon was observed. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
