| 灯盏细辛对缺血性脑卒中侧支循环形成作用的临床观察 |
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| 引用本文： | 周凯,吴俊宏,梁护,黄格朗. 灯盏细辛对缺血性脑卒中侧支循环形成作用的临床观察[J]. 新医学, 2022, 53(10): 740-745. DOI: 10.3969/j.issn.0253-9802.2022.10.007 |
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| 作者姓名： | 周凯 吴俊宏 梁护 黄格朗 |
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| 作者单位： | 537100 贵港,广西贵港市人民医院康复科（周凯,梁护,黄格朗）,放射科（吴俊宏） |
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| 基金项目： | 广西壮族自治区卫生和计划生育委员会科研课题(Z20180121) |
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| 摘 要： | 目的 通过CT灌注成像（CTP）观察缺血性脑卒中患者侧支循环形成的情况，探讨灯盏细辛改善脑循环的作用机制。方法 选择60例缺血性脑卒中住院患者，随机分为治疗组（32例）和对照组（28例）。研究过程中治疗组脱落3例、对照组脱落2例，最后治疗组纳入29例、对照组纳入26例。2组患者入院后均接受常规治疗，治疗组患者在此基础上静脉滴注灯盏细辛注射液，对照组患者静脉滴注等量生理盐水，连续治疗2周。分别于患者入院第1日（治疗前）和入院第30日行CTP检查，记录患者患侧病灶侧感兴趣区域（ROI）的脑血流量（CBF）、脑血容量（CBV）、达峰时间（TTP）和平均通过时间（MMT）；并于治疗前、治疗第14日及入院第30日采集患者外周静脉血检测血清血管内皮生长因子（VEGF）、缺氧诱导因子-1α(HIF-1α)、血管生成素-1(Ang-1)水平并进行美国国立卫生研究院卒中量表（NIHSS）、Barthel指数（BI）评分，比较2组患者上述各指标的差异。结果 2组患者在入院第30日的CBF、CBV均比治疗前升高，TTP、MMT时间比治疗前缩短（P均<0.05）。在治疗第14日，2组的血清VEGF、HI...
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| 关 键 词： | 侧支循环 灯盏细辛 脑卒中 CT灌注成像 细胞因子 |
| 收稿时间： | 2022-02-18 |
Effect of Erigeron breviscapus on collateral circulation in patients with ischemic stroke |
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| Zhou Kai,Wu Junhong,Liang Hu,Huang Gelang. Effect of Erigeron breviscapus on collateral circulation in patients with ischemic stroke[J]. New Chinese Medicine, 2022, 53(10): 740-745. DOI: 10.3969/j.issn.0253-9802.2022.10.007 |
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| Authors: | Zhou Kai Wu Junhong Liang Hu Huang Gelang |
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| Affiliation: | △Rehabilitation Department, Guigang City People’s Hospital, Guigang 537100, China |
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| Abstract: | Objective To explore the mechanism of Erigeron breviscapus on improving cerebral circulation in patients with ischemic stroke by observing the formation of collateral circulation using CT perfusion imaging （CTP）. Methods Sixty ischemic stroke patients were selected and randomly divided into the treatment （n = 32） and control groups （n = 28）. During the study, there were 3 patients dropped in the treatment group and 2 patients dropped in the control group. Finally, there were 29 cases enrolled in the treatment group and 26 cases enrolled in the control group. All patients in two groups received routine treatment. In the treatment group, intravenous injection of Erigeron breviscapus was given for 2 weeks, and an equivalent amount of normal saline was administered for 2 weeks in the control group. CTP was performed at 1 d after admission （before treatment） and 30 d after admission. Time-point measurement of cerebral blood flow （CBF）, cerebral blood volume （CBV）, time to the peak （TTP） and mean transit time （MMT） of the region of interest （ROI） on the affected side was recorded. Serum levels of vascular endothelial growth factor （VEGF）, hypoxia inducible factor-1α （HIF-1α）, angiopoietin -1 （Ang-1） were detected before and 14 d after treatment, and 30 d after admission, respectively. The National Institute of Health Stroke Scale （NIHSS） and Barthel index （BI） scores were measured. All these indexes were statistically compared between two groups. Results In both groups, CBF and CBV were significantly increased, whereas TTP and MMT at 30 d after admission were significantly shortened compared with those before treatment （all P < 0.05）. In the treatment group, the expression levels of serum VEGF and Ang-1 at 14 d after treatment were significantly up-regulated, whereas significantly down-regulated at 30 d after admission compared with those before treatment, and the expression level of HIF-1α was gradually down-regulated （all P < 0.017）. At 14 d after treatment and 30 d post-admission, the NIHSS score was significantly lower, where the BI score was significantly higher in the treatment group compared with those in the control group （both P < 0.05）. Conclusion Erigeron breviscapus can promote collateral circulation formation, alleviate neurological deficits and improve daily living ability in patients with ischemic stroke, which may be associated with dynamic changes of VEGF, HIF-1α and Ang-1, especially the Ang-1. |
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| Keywords: | Collateral circulation Erigeron breviscapus Stroke CT perfusion imaging Cytokine |
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