In Vitro Activity of HR 756, a New Cephalosporin, Against Neisseria gonorrhoeae |
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| Authors: | Patrick R. Murray Judy L. Christman Gerald Medoff |
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| Affiliation: | 1Clinical Microbiology Laboratory, Barnes Hospital, and Infectious Disease Division, Washington University School of Medicine, Saint Louis, Missouri 63110 |
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| Abstract: | The in vitro activity of HR 756 was compared with penicillin, cefamandole, cefoxitin, and tetracycline against Neisseria gonorrhoeae. A total of 192 randomly selected isolates (of which 23 had minimal inhibitory concentrations of >/=0.5 mug/ml for penicillin) and three beta-lactamase-producing isolates were tested. HR 756 was the most active antibiotic tested, with more than 90% of the isolates inhibited by 0.008 mug/ml and all inhibited by 0.25 mug/ml. |
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