| 环维黄杨星D对大鼠心脏功能及血压的作用 |
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| 引用本文： | 杨芳芳,胡申江. 环维黄杨星D对大鼠心脏功能及血压的作用[J]. 中国药理学与毒理学杂志, 2007, 21(4): 255-258 |
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| 作者姓名： | 杨芳芳 胡申江 |
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| 作者单位： | 浙江大学医学院附属第一医院,浙江,杭州,310003 |
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| 摘 要： | 目的观察环维黄杨星D(CVB-D)对正常大鼠在体心脏功能和血压的调节作用。方法雄性SD大鼠灌胃给予CVB-D 3.35 mg·kg~(-1)·d~(-1),分别于给药2,4和6周后,用血流动力学方法观察大鼠的收缩压、舒张压、左室收缩压(LVSP)、左室舒张末压(LVEDP)、左室压力最大变化速率(±dp/dt_(max))以及心率。结果与对照组相比,灌胃给予CVB-D 6周后,大鼠LVSP增高,收缩压降低。而各时间点给药组LVEDP、±dp/dt_(max)、舒张压及心率均未发生明显改变。结论CVB-D对在体大鼠有一定的增强心脏功能和降低主动脉压力效应,同时不会引起心动过速。
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| 关 键 词： | 环维黄杨星D 血流动力学 心脏收缩 |
| 文章编号： | 1000-3002（2007）04-0255-04 |
| 收稿时间： | 2006-09-05 |
| 修稿时间： | 2006-09-052007-03-08 |
Effect of cyclovirobuxine-D on heart function and blood pressure of rats in vivo |
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| YANG Fang-Fang,HU Shen-Jiang. Effect of cyclovirobuxine-D on heart function and blood pressure of rats in vivo[J]. Chinese Journal of Pharmacology and Toxicology, 2007, 21(4): 255-258 |
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| Authors: | YANG Fang-Fang HU Shen-Jiang |
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| Affiliation: | The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China |
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| Abstract: | AIM To explore effects of cyclovirobuxine-D (CVB-D) on heart function and blood pressure of rats in vivo . METHODS CVB-D 3.35 mg·kg-1·d-1 was given (ig) to male SD rats for 2, 4 and 6 weeks, then proceeded in vivo hemodynamic measurements through right carotid artery. Left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), maximal rate of rise and decline of left ventricular pressure (±dp/dtmax), systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were detected by the Medlab 6 system. RESULTS No significant differences were observed in 2-week and 4-week groups. LVSP elevated notably in 6-week CVB-D group，while SBP decreased. LVEDP, ±dp/dtmax, DBP and HR stayed stable in two groups. CONCLUSION CVB-D can improve heart function and lower blood pressure, while not quickening the heart rate synchronously. |
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| Keywords: | cyclovirobuxine D hemodynam-ics myocardial contraction |
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