| NGAL MMP-9和E-cadherin在结肠癌中的表达及其与预后的关系 |
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| 引用本文： | 高钧, 孙燕, 赵秀兰, 孙保存. NGAL MMP-9和E-cadherin在结肠癌中的表达及其与预后的关系[J]. 中国肿瘤临床, 2011, 38(6): 324-327 . DOI: 10.3969/j.issn.1000-8179.2011.06.007 |
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| 作者姓名： | 高钧 孙燕 赵秀兰 孙保存 |
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| 作者单位： | 天津医科大学附属肿瘤医院病理科 |
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| 摘 要： | 目的：探讨NGAL、E-cadherin和MMP-9在结肠癌复发与转移中的作用及与预后的相关性。方法： 回顾性分析天津医科大学附属肿瘤医院2000年1月～2004年12月227例结肠癌患者的临床资料， 总结其病理特征及随访结果， 并将227例病例对应的石蜡标本制作成组织芯片， 其中复发与转移组83例， 无复发转移组144例， 用免疫组织化学法检测结肠癌组织中NGAL、E-cadherin和MMP-9的表达， 分析其与复发转移及预后的关系。结果： 复发转移组NGAL、 MMP-9表达高于无复发转移组 （P=0.032； P=0.000）， 复发与转移组E-cadherin表达低于无复发转移组 （P=0.030）。NGAL、 MMP-9阳性组平均生存时间分别为（47.427±2.505） 个月、（48.081±2.672） 个月， 中位生存时间分别为37、 35个月， 阴性组平均生存时间分别为 （65.714±3.616） 个月、（69.598±2.073） 个月， 中位生存时间分别为77、 75个月， NGAL、 MMP-9阳性组生存期较阴性组缩短， 差别具有统计学意义 （P=0.000， P=0.010）。E-cadherin阳性组平均生存时间为 （61.587±2.805） 个月，中位生存时间为61个月， E-cadherin阴性组为 （39.535±2.946） 个月， 中位生存时间为23个月， E-cadherin阳性组生存时间较阴性组延长， 有统计学意义 （P=0.000）。结论： NGAL、 MMP-9过度表达， E-cadherin表达缺失可能与结肠癌复发、 转移， 不良生存预后存在相关性。
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| 关 键 词： | NGAL MMP-9 E-cadherin 结肠癌 复发与转移 |
| 收稿时间： | 2010-11-25 |
| 修稿时间： | 2011-01-02 |
The Expression of NGAL, MMP-9 and E-cadherin in Colon Carcinoma and Its Correlation with Recurrence, Metastasis and Prognosis |
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| Jun GAO,Yan SUN,Xiulan ZHAO,Baocun SUN. The Expression of NGAL, MMP-9 and E-cadherin in Colon Carcinoma and Its Correlation with Recurrence, Metastasis and Prognosis[J]. Chinese Journal of Clinical Oncology, 2011, 38(6): 324-327. DOI: 10.3969/j.issn.1000-8179.2011.06.007 |
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| Authors: | Jun GAO Yan SUN Xiulan ZHAO Baocun SUN |
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| Abstract: | The Expression of NGAL, MMP-9 and E-cadherin in Colon Carcinoma and Its Correlationwith Recurrence, Metastasis and PrognosisJun GAO1, Yan SUN1, Xiulan ZHAO2, Baocun SUN2Correspondence to: Baocun SUN, E-mail: baocunsun@gmail.com1Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Thera-py, Tianjin 300060, China2Department of Pathology, Tianjin Medical University, Tianjin 300070, ChinaAbstract Objective: To investigate the effects of NGAL, MMP-9 and E-cadherin on the recurrence and metastasis of colon car-cinoma and its correlation with clinical prognosis. Methods: Clinical characteristics and prognosis of 227 colon carcinoma patients di-agnosed between 2000 and 2004 were reviewed. The paraffin embedded tissue samples were selected and tissue microarray blocks weremade ( 83 with recurrence and metastasis and 144 without recurrence and metastasis ). Immunohistochemical staining was used to eval-uate the expression of NGAL, MMP-9 and E-cadherin in colon carcinoma and its correlation with recurrence and metastasis in coloncarcinoma was analyzed. Results: The abnormal expression of NGAL and MMP-9 in the recurrence and metastasis group was higherthan that in the group without recurrence or metastasis ( P = 0.032, P = 0.000 ). The positive ratio of E-cadherin in the recurrence andmetastasis group was lower than that in the group without recurrence or metastasis ( P = 0.030 ). The mean survival was 47.427 ± 2.505months in patients with positive expression of NGAL and 48.081 ± 2.672 months in patients with positive expression of MMP-9. Themedian survival time was 37 and 35 months, respectively. The mean survival time was 65.714 ± 3.616 months in patients withoutNGAL expression and 69.598 ± 2.073 months in patients without MMP-9 expression. The median survival time was 77 and 75 months,respectively. The survival of patients with positive expression of NGAL and MMP-9 was shorter than that of patients with negative ex-pression of NGAL and MMP-9 ( P = 0.000, P = 0.010 ). The mean survival time and median survival time of patients with E-cadherinexpression were 61.587 ± 2.805 months and 61 months, significantly higher than those in patients without E-cadherin expression ( P =0.000 ), which were 39.535 ± 2.946 months and 23 months, respectively. Conclusion: The overexpression of NGAL and MMP-9 anddecreased expression of E-cadherin may play critical roles in the recurrence and metastasis of colon carcinoma and indicate a poorerprognosis.Keywords NGAL; MMP-9; E-cadherin; Colon carcinoma; Recurrence and metastasis |
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| Keywords: | NGAL MMP-9 E-cadherin |
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