| CLDN18表达在胃癌进展中的意义 |
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| 引用本文： | 王行富, 张 声, 郑 珂, 陈 虹, 陈林莺, 陈余朋. CLDN18表达在胃癌进展中的意义[J]. 中国肿瘤临床, 2011, 38(11): 642-646. DOI: 10.3969/j.issn.1000-8179.2011.11.011 |
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| 作者姓名： | 王行富 张声 郑珂 陈虹 陈林莺 陈余朋 |
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| 作者单位： | 福建医科大学附属第一医院病理科 (福州市350005) |
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| 基金项目： | 本文课题受福建省教育厅科技项目 |
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| 摘 要： | 探讨CLDN18表达与胃癌临床病理特征之间的关系。方法：组织芯片免疫组化染色法检测胃癌claudin-18蛋白表达，Real-time PCR法检测胃癌CLDN18 mRNA的表达。结果：胃癌组织claudin-18表达显著降低，并与组织学类型和浸润相关，肠型胃癌和浸润在肌层以内者其黏膜层claudin-18的下调表达率明显高于弥漫型胃癌或浸润程度超过肌层者。从黏膜层进展至侵袭前缘区，claudin-18的下调表达率逐渐升高，黏膜层claudin-18表达水平明显高于侵袭前沿区。进展期胃癌黏膜层癌组织claudin-18表达未下调者34例进展至侵袭前沿区28例转变为表达下调，其中弥漫型胃癌、浸润程度超过肌层者、有淋巴结转移者以及非贲门胃癌者发生率均高于肠型胃癌、浸润程度在肌层内者、无淋巴结转移者以及贲门胃癌者。52例胃癌黏膜层胃癌组织CLDN18 mRNA表达下调者20例，其相对表达量与浸润程度及肿瘤大小有关。结论：胃癌的进展中claudin-18表达降低，组织学类型的维持与其密切相关。
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| 关 键 词： | 胃癌 CLDN18 claudin-18 侵袭 转移 |
| 收稿时间： | 2010-12-09 |
| 修稿时间： | 2011-03-21 |
Significance of CLDN18 Expression in Gastric Cancer Progression |
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| Xingfu WANG, Sheng ZHANG, Ke ZHENG, Hong CHEN, Linying CHEN, Yupeng CHEN. Significance of CLDN18 Expression in Gastric Cancer Progression[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2011, 38(11): 642-646. DOI: 10.3969/j.issn.1000-8179.2011.11.011 |
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| Authors: | Xingfu WANG Sheng ZHANG Ke ZHENG Hong CHEN Linying CHEN Yupeng CHEN |
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| Affiliation: | Department of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China |
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| Abstract: | To study relationship between CLDN18 gene expression and the clinicopathologic features of gastric cancer ( GC ). Methods: A tissue microarray was made and immunohistochemistry was performed to detect the expression of claudin-18 protein. Real-time polymerase chain reaction was conducted to examine mRNA expression of CLDN18 gene. Results: Expression of claudin-18 protein in GC was significantly downregulated and was correlated with histologic types and extent of invasion, which was greatly decreased in the intestinal-type and intramuscular infiltration of GC than in the diffuse-type and the extramuscular extension, respectively. There was a gradual downregulation of claudin-18 expression from the mucosa to the front of the invasion. Claudin-18 expression was higher in the mucosa than at the front of invasion. Of the 34 cases with advanced GC without downregulation of claudin-18 expression in mucosa, 28 had claudin-18 downregulation as GC developed to the front of the invasion. In the 28 cases, the incidences of the diffuse-type GC, extramuscular infiltration, lymph node metastasis, and non-cardiac GC were higher compared with the intestinal-type, intramuscular, non-metastatic, and cardiac GC. CLDN18 mRNA expression was downregulated in 20 of the 52 GC cases. The relative expression was associated with the infiltration and size of the tumors. Conclusion: Downregulation of claudin-18 expression is involved in the progression of disease, and in maintaining the phenotype of gastric adenocarcinoma. |
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| Keywords: | CLDN18 claudin-18 |
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