Nonimmune interaction of the SfbI protein of Streptococcus pyogenes with the immunoglobulin G F(ab')(2) fragment |
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| Authors: | Medina E Schulze K Chhatwal G S Guzmán C A |
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| Affiliation: | Department of Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF-German Research Centre for Biotechnology, D-38124 Braunschweig, Germany. |
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| Abstract: | Fibronectin-binding protein I (SfbI) of Streptococcus pyogenes binds to mouse immunoglobulin G (IgG) but not to IgA or IgM in a nonimmune fashion. The fibronectin-binding domains of SfbI were responsible for this activity, which was targeted to the IgG F(ab')(2) fragment. SfbI also binds to B cells but not to CD4(+) or CD8(+) lymphocytes. |
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