| 牙周治疗干预类风湿性关节炎的系统评价 |
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| 引用本文： | Lü Z,Li C,Lü J,He W,Gao L,Wu Y. 牙周治疗干预类风湿性关节炎的系统评价[J]. 华西口腔医学杂志, 2011, 29(4): 375-378. DOI: 10.3969/j.issn.1000-1182.2011.04.011 |
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| 作者姓名： | Lü Z Li C Lü J He W Gao L Wu Y |
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| 作者单位： | 1.四川大学华西口腔医院牙周科; 2.四川大学华西口腔医学院口腔颌面外科教研室;3.口腔疾病研究国家重点实验室, 四川大学, 成都610041 |
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| 基金项目： | 四川大学大学生科研训练计划基金资助项目(20101071) |
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| 摘 要： | 目的 评价牙周治疗措施在缓解类风湿性关节炎(RA)患者症状和体征中的效果及安全性.方法 电子检索Medline(OVID,1950年-2010年9月)、荷兰医学文摘(EMBASE,1984年-2010年9月)、Cochrane图书馆临床随机对照试验库(CENTRAL,2010年第3期)、中国生物医学文献数据库(1978...
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| 关 键 词： | 牙周治疗 牙周炎 类风湿性关节炎 系统评价 循证口腔医学 |
| 收稿时间： | 2011-08-25 |
| 修稿时间： | 2011-08-25 |
Periodontal therapy for rheumatoid arthritis: a systematic review |
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| Lü Zongkai,Li Chunjie,Lü Jun,He Wulin,Gao Li,Wu Yafei. Periodontal therapy for rheumatoid arthritis: a systematic review[J]. West China journal of stomatology, 2011, 29(4): 375-378. DOI: 10.3969/j.issn.1000-1182.2011.04.011 |
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| Authors: | Lü Zongkai Li Chunjie Lü Jun He Wulin Gao Li Wu Yafei |
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| Affiliation: | 1. Dept. of Periodontology, West China School of Stomatology, Sichuan University, Chengdu 610041, China; 2. Dept. of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu 610041, China; 3. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China |
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| Abstract: | Objective To assess the effect and safety of periodontal therapy in relieving the symptoms and clinical signs of rheumatoid arthritis（RA）. Methods The electronic search was conducted in Medline（OVID, 1950—2010 Sep）, EMBASE（1984—2010 Sep）, CENTRAL（2010, Issue 3）,CBM（1978—2010 Sep） and the Chinese journals on stomatology were hand-searched. Clinical randomized controlled trials as well as clinical controlled trials were selected regarding the targeted issue. Two investigators evaluated the reporting quality and risk of bias of those included trials in accordance with CONSORT statement and Cochrane risk of bias assessment tools, and collected data of included studies in duplicate. Revman 5.0.23 was applied for Meta-analysis. Results Four trials met the inclusion criteria and a total of 150 patients were enrolled in the trials, one had low risk of bias and others had moderate risk of bias. Metaanalysis showed that pure periodontal therapy could not decrease disease activity score in 28 joints（DAS28）（P=0.06）, and there was no statistically significant difference between periodontal therapy with anti-tumor necrosis factor-α（TNF- α） medication and pure anti-TNF-α medication（P=0.24）. But the subgroup analysis showed that a significantly decreased DAS28 was achieved by periodontal therapy（P=0.03）, and the interventions provided a remarkable effect on alleviating clinical signs and erythrocyte sedimentation rate of RA（P<0.05）. Results of the symptoms relief differed from the studies. No adverse events were reported. Conclusion The evidence available currently indicates that periodontal therapy may play a positive role in remitting the clinical signs and periodontal status of RA except the relief of the symptoms. |
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| Keywords: | periodontal therapy periodontitis rheumatoid arthritis systematic review evidence based dentistry |
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