| 信号通路调控骨髓间充质干细胞成骨分化的研究 |
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| 引用本文： | 周陈晨,吴祖平,邹淑娟. 信号通路调控骨髓间充质干细胞成骨分化的研究[J]. 四川大学学报(医学版), 2020, 51(6): 777-782. DOI: 10.12182/20201160103 |
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| 作者姓名： | 周陈晨 吴祖平 邹淑娟 |
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| 作者单位： | 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院 （成都 610041） |
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| 基金项目： | 中国博士后科学基金面上资助项目;国家自然科学基金青年科学基金项目 |
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| 摘 要： | 骨髓间充质干细胞的成骨分化受到多条信号通路调控,直接或间接影响矮小相关转录因子2（runt-related transcription factor 2, Runx2）和成骨细胞特异性转录因子（osterix, Osx）等成骨关键转录因子的表达,在骨的发育与再生、骨的修复重建过程中发挥了关键作用。这些通路各自发挥其作用机制,但又相互交织关联构成了一个复杂的信号调控网络,但由于研究手段的局限,成骨分化相关信号通路的具体作用机制仍不明了,若能阐明这些不同的信号通路各自发挥其作用的相关机制及各条通路之间的相互关系,对成骨分化的机制研究具有重要的意义。本文将对各种信号通路在骨髓间充质干细胞成骨分化调控研究中所取得的进展做一综述。
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| 关 键 词： | 骨髓间充质干细胞 成骨分化 信号通路 |
| 收稿时间： | 2020-06-18 |
The Study of Signal Pathway Regulating the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells |
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| ZHOU Chen-chen,WU Zu-ping,ZOU Shu-juan. The Study of Signal Pathway Regulating the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells[J]. Journal of Sichuan University. Medical science edition, 2020, 51(6): 777-782. DOI: 10.12182/20201160103 |
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| Authors: | ZHOU Chen-chen WU Zu-ping ZOU Shu-juan |
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| Affiliation: | State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China |
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| Abstract: | Osteogenesis of mesenchymal stem cells to differentiate between bone marrow by multiple signaling pathways that control, directly or indirectly affect small related transcription factor 2 (runt-related transcription factor 2, Runx2) and osteoblast specific transcription factor (osterix, Osx), the expression of osteogenesis key transcription factors, such as in the development and regeneration of the bone, bone repair has played a key role in the process of reconstruction. These pathways play their mechanism of action, but also intertwined associated constitute a complex signal transduction network, but due to the limitations of research methods, the osteogenic differentiation related signaling pathways of the specific mechanism is still unclear, if you can clarify these different signaling pathways play to the role of their relevant mechanism and the relationship between various pathways and the mechanism study of osteogenesis differentiation is of great importance. This article will review the progress of various signaling pathways in the regulation of osteogenic differentiation of bone marrow mesenchymal stem cells. |
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