| 地高辛低血浓度与慢性心力衰竭的疗效 |
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| 引用本文： | 赵晓静,彭卓,屈莉,王锦秋,李丽君. 地高辛低血浓度与慢性心力衰竭的疗效[J]. 心脏杂志, 2009, 21(2): 248-250 |
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| 作者姓名： | 赵晓静 彭卓 屈莉 王锦秋 李丽君 |
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| 作者单位： | 西安交通大学第二医院:1.急诊科，2.药理研究室，陕西 西安 710004 |
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| 摘 要： | 目的 探讨中国人地高辛治疗心衰的有效血药浓度。方法 心力衰竭患者口服地高辛0.125～0.25 mg/d, 3 d后改为0.0625~0.125 mg/d维持，依据服药1周后地高辛血药浓度(SDC)分组，低浓度组（SDC≤0.4 μg/L） 57例，中浓度组（0.4 μg/L
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| 关 键 词： | 心力衰竭 慢性 地高辛 血药浓度 |
Lower serum digoxin concentration and therapeutic effect on chronic heart failure |
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| ZHAO Xiao-jing,PENG Zhuo,QU Li,WANG Jin-qiu,LI Li-jun. Lower serum digoxin concentration and therapeutic effect on chronic heart failure[J]. Chinese Heart Journal, 2009, 21(2): 248-250 |
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| Authors: | ZHAO Xiao-jing PENG Zhuo QU Li WANG Jin-qiu LI Li-jun |
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| Abstract: | AIM To investigate the effects of lower serum digoxin concentration (SDC, SDC<0.4 μg/L) on heart failure (HF) in Chinese population. METHODS Patients with HF took digoxin: 0.125-0.25 mg daily for three days and then 0.125 mg or 0.0625 mg once a day. All the patients were divided into three groups according to the SDC one week after taking digoxin: the low SDC group (SDC≤0.4 μg/L), middle SDC group (0.4 μg/L0.05). The arrhythmia rate in the high and middle SDC groups was significantly higher than that in the low SDC group (P<0.05). CONCLUSION Mortality rate and arrhythmia rate were higher in high SDC group compared with those in middle and low groups. The low SDC (0.31±0.08) μg/L is safer but as effective as middle and high SDC in HF in chinese population. |
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