| 西尼地平的合成及其药理作用研究进展 |
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| 引用本文： | 周蕾,郄文娟. 西尼地平的合成及其药理作用研究进展[J]. 新乡医学院学报, 2007, 24(2): 211-213 |
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| 作者姓名： | 周蕾 郄文娟 |
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| 作者单位： | 白求恩军医学院文化教研室 |
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| 摘 要： | 西尼地平是兼具有L型和N型钙通道阻滞作用的新型钙拮抗剂。它不仅可以有效地降低血压,还可以有效预防反射性交感神经兴奋,和该药的其他有益作用一起,对减轻高血压的靶器官损害有一定作用。临床主要用于轻、中度高血压的治疗,疗效优于硝苯地平、尼莫地平等药物。作者介绍了国内外近年来西尼地平的合成及药理作用研究进展情况。
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| 关 键 词： | 西尼地平 合成 药理作用 综述 |
| 文章编号： | 1004-7239（2007）02-0211-03 |
| 收稿时间： | 2006-12-22 |
| 修稿时间： | 2006-12-22 |
Advance in synthesis and pharmacological action of cilnidipine |
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| ZHOU Lei,QIE Wen-juan. Advance in synthesis and pharmacological action of cilnidipine[J]. Journal of Xinxiang Medical College, 2007, 24(2): 211-213 |
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| Authors: | ZHOU Lei QIE Wen-juan |
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| Affiliation: | Department of Culture, Bethune Military Medical College, Shijiazhuang 050081, China |
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| Abstract: | Cilnidipine was a novel dihydropyridin calcium antagonist including type L and Type N calcium channel.Cilnidipine can effectively inhibit reflex overactivity of SNS besides its hypotensive action.Together with its other pharmacological effects,cilnidipine might protect target organs from lesion.It is mainly adopted for treatment of mild and moderate hypertensive and is better than nifedipine and nimodipine.In this paper,synthesis of cilnidipine and its pharmacological action were introduced and reviewed. |
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| Keywords: | cilnidipine synthesis pharmacological action review |
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