首页 | 本学科首页   官方微博 | 高级检索  
     


A comparison of murine and human immunoproteomes of Helicobacter pylori validates the preclinical murine infection model for antigen screening
Authors:Bumann Dirk  Holland Petra  Siejak Frank  Koesling Jan  Sabarth Nicolas  Lamer Stefanie  Zimny-Arndt Ursula  Jungblut Peter R  Meyer Thomas F
Affiliation:Department of Molecular Biology, Max-Planck-Institute for Infection Biology, Berlin, Germany.
Abstract:Preclinical mouse infection models are widely used for Helicobacter vaccine development, but how well such models mimic important aspects of human infections is unknown. A comparison of Helicobacter pylori immunoproteomes of infected mice with previously reported patient data reveals a high agreement in the antigens recognized, suggesting that H. pylori in vivo protein composition and recognition by the host immune system are comparable in mice and humans. Murine Helicobacter models may thus be valid to screen antigens for human vaccination.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号