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DNA methylation profiling of pediatric B‐cell lymphoblastic leukemia with KMT2A rearrangement identifies hypomethylation at enhancer sites
Authors:Anke K. Bergmann  Giancarlo Castellano  Julia Alten  Ole Ammerpohl  Julia Kolarova  Jessica Nordlund  Jose Ignacio Martin‐Subero  Martin Schrappe  Reiner Siebert
Affiliation:1. Institute of Human Genetics, Christian‐Albrechts‐University Kiel & University Hospital Schleswig‐Holstein, Campus Kiel, Kiel, Germany;2. Department of Pediatrics, Christian‐Albrechts‐University Kiel & University Hospital Schleswig‐Holstein, Campus Kiel, Kiel, Germany;3. Departamento de Anatomía Patológica, Farmacología y Microbiología, Institutd'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain;4. Institute of Human Genetics, University of Ulm & University Medical Center Ulm, Ulm, Germany;5. Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Sweden
Abstract:
Keywords:acute lymphoblastic leukemia  DNA methylation  enhancer hypomethylation  infant ALL  KMT2A rearrangements
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