IFR4/MUM1‐positive lymphoma in Waldeyer ring with co‐expression of CD5 and CD10 |
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| Authors: | Lei Chen Lika'a Fasih Y. Al‐Kzayer Tingting Liu Norimoto Kobayashi Yozo Nakazawa Kenichi Koike |
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| Affiliation: | 1. Department of Pathology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China;2. Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan;3. Department of Pediatric Hematology/Oncology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China |
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| Abstract: | IRF4/MUM1‐positive lymphoma is a new subgroup of germinal center‐derived B‐cell lymphoma, predominantly involving the Waldeyer ring (WR) in children. CD5 expression is rare in these lymphomas. We report a 7‐year‐old Chinese male with B‐cell lymphoma. Evaluation of his specimen by morphology, immunohistochemistry, and FISH analysis demonstrated IRF4/MUM1‐positive lymphoma with strong and extensive CD5 and CD10 positivity. Despite the lack of t(14;18)(q32;q21) rearrangement, BCL2 protein was expressed. Our report highlights the clinicopathologic features of IFR4/MUM1‐positive lymphoma in WR with co‐expression of CD5 and CD10, and thereby provides insight into this newly recognized disease entity. |
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| Keywords: | CD5 IRF4/MUM1‐positive lymphoma pediatric follicular lymphoma Waldeyer ring |
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