| 医院就诊女性宫颈人乳头瘤病毒感染现状 |
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| 引用本文： | 施文平, 徐嘉琳, 毛燕燕, 张乐平, 寇嘉宁, 张妍, 李敏, 周维谨, 朱虔兮. 医院就诊女性宫颈人乳头瘤病毒感染现状[J]. 中国公共卫生, 2015, 31(4): 434-437. DOI: 10.11847/zgggws2015-31-04-15 |
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| 作者姓名： | 施文平 徐嘉琳 毛燕燕 张乐平 寇嘉宁 张妍 李敏 周维谨 朱虔兮 |
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| 作者单位： | 1.上海市计划生育科学研究所 国家人口计生委计划生育药具重点实验室, 上海 200237;;2.上海市第八人民医院妇产 科;;3.复旦大学公共卫生学院 |
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| 基金项目： | 国家自然科学基金青年基金(81102172) |
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| 摘 要： | 目的 分析上海市医院门诊就诊女性宫颈人乳头瘤病毒(HPV)感染状况及亚型分布特点.方法 收集2009年5月-2012年12月在上海市第八人民医院门诊就诊的2 701例女性宫颈HPV检测资料,对HPV感染现状及亚型分布特点进行分析.结果 检出21种HPV亚型,总感染率为33.65%,感染率最高的亚型是HPV16(6.85%)和HPV52(6.85%),其他常见亚型为HPV58(6.18%)、HPV53(3.74%)和HPV11(3.70%);16~45岁感染数占总感染数的83.82%,各年龄组感染率差异有统计学意义,低年龄组(16~25岁)感染率最高(36.82%),高年龄组(≥66岁)最低(16.36%);个体感染亚型种类数最多检出7种,单一亚型感染率为22.84%,多重感染率为10.81%,高危型感染率为24.58%,低危型为4.59%,高低危混合型为4.48%;高危型感染中以26~35岁感染率最高,低危型感染以16~25岁最高,混合型感染以≥66岁最高.结论 上海市医院就诊女性宫颈HPV感染最常见亚型为HPV16、HPV52、HPV58、HPV53和HPV11,感染呈现以单一亚型、高危感染和16~45岁感染为主,多重感染并存的特征.
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| 关 键 词： | 人乳头瘤病毒 多重感染 高危型感染 年龄 |
| 收稿时间： | 2013-12-12 |
Prevalence of human papillomavirus infection in gynecologic outpatients in Shanghai |
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| SHI Wen-ping, XU Jia-lin, MAO Yan-yan.et al, . Prevalence of human papillomavirus infection in gynecologic outpatients in Shanghai[J]. Chinese Journal of Public Health, 2015, 31(4): 434-437. DOI: 10.11847/zgggws2015-31-04-15 |
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| Authors: | SHI Wen-ping XU Jia-lin MAO Yan-yan.et al |
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| Affiliation: | 1.Shanghai Institute of Planned Parenthood, Shanghai, 200237, China |
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| Abstract: | Objective To analyse infection status and subgenotype distribution characteristics of human papillomavirus(HPV) in gynecologic outpatients.Methods Totally 2 701 outpatients visiting Gynecologic Department of the Eighth People's Hospital of Shanghai between May 2009 and December 2012 were selected.The outpatients were detected for 21 HPV genotypes by reverse DNA dot hybridization technique.Results The overall HPV infection rate among the outpatients was 33.65%.For the 21 HPV subgenotypes,the infection rate of HPV 16(6.85%) and HPV 52(6.85%) were the highest,and that of HPV 58,HPV53 and HPV11 were 6.18%,3.74% and 3.70%,respectively.Up to 83.82% of the infected women were between the age of 16 to 45 years.The infection rate of different age group was different significantly.The infection rate of women aged 16 to 25 years was the highest(36.82%),while the women more than 66 years old was the lowest(16.36%).There were up to 7 HPV subtypes being detected positively in one woman.The single subtype infection rate was 22.84% and the multiple infection rate was 10.81%.The high-risk subtype infection rate was 24.58%,while the low-risk subtype was 4.59%,and the high and low risk mixed infection rate was 4.48%.The rates of high,low,and high-low risk mixed infection rate among the women of various age were significantly different.For high-risk subtype infection,the infection rate of the women aged 26 to 35 years was the highest,while the women aged 16-25 years had the higest low-risk infection rate and the women more than 66 year old had the highest high-low risk mixed infection rate.Conclusion The most common HPV subtype infection were HPV 16,52,58,53 and HPV 11 and for the women aged 16 to 45 years,single HPV subtype infection and high-risk HPV infection were common,with multiple subtypes HPV infeetion among the women in Shanghai. |
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| Keywords: | human papillomavirus(HPV) multiple infection high-risk infection age |
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