| .布地奈德联合特布他林压缩雾化吸入治疗慢性阻塞性肺疾病急性加重期的疗效观察[J].中国现代医生,2018,(9):115-117 |
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| 布地奈德联合特布他林压缩雾化吸入治疗慢性阻塞性肺疾病急性加重期的疗效观察 |
| Observation on the effect of budesonide combined with terbutaline compressed atomizing inhalation in the treatment of acute exacerbation of chronic obstructive pulmonary disease |
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| 关键词: 慢性阻塞性肺疾病急性加重期 布地奈德 特布他林 肺功能 |
| Key Words:Acute exacerbation of chronic obstructive pulmonary disease Budesonide Terbutaline Pulmonary function |
| 基金项目:浙江省医药卫生科技计划（2017KY617） |
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| 摘要:目的 观察布地奈德联合特布他林压缩雾化吸入治疗慢性阻塞性肺疾病急性加重期的临床治疗效果。方法 选择2016年10月～2017年10月在我院住院治疗的COPD急性加重期患者80例，按照治疗方法的不同分为对照组和观察组，各40例，两组均予抗炎、祛痰、止咳、平喘、低流量吸氧等常规治疗；观察组同时联合布地奈德雾化液1 mg和硫酸特布他林雾化液5 mg压缩雾化吸入，每次15 mL，2次/d，连续治疗14 d。治疗后对两组的临床疗效、肺功能及用药安全性进行评价。结果 治疗后，观察组患者治疗后的临床总有效率明显高于对照组，差异有统计学意义（90%vs 70%，χ2=6.783，P＜0.05），两组治疗后的 FEV1、FVC、FEV1/FVC 较治疗前明显升高，且观察组明显高于对照组，差异有统计学意义（P<0.05）。结论 布地奈德联合特布他林压缩雾化吸入治疗COPD急性加重期疗效确切，可以显著缓解患者的临床症状，改善肺功能，值得临床推广和应用。 |
| Abstract:Objective To observe the clinical effect of budesonide combined with terbutaline compressed atomizing inhalation in the treatment of acute exacerbation of chronic obstructive pulmonary disease.Methods 80 patients with acute exacerbation of COPD who were hospitalized in our hospital from October 2016 to October 2017 were enrolled in this study.In accordance with the different treatment methods,the patients were divided into the control group and the observation group,with 40 cases in each group.Both groups were given anti-inflammation,expectorant,cough,asthma,low flow oxygen and other conventional treatment；the observation group was also combined with budesonide aerosol of 1 mg and terbutaline sulphate aerosol of 5 mg for compressed atomizing inhalation,with 15 mL for each dose,twice a day.The treatment lasted for 14 days.After treatment,the clinical efficacy,lung function and drug safety of the two groups were evaluated.Results After treatment,the total clinical effective rate in the observation group was significantly higher than that in the control group after treatment,and the differences were statistically significant（90%vs 70%,χ2=6.783,P<0.05）.The FEV1,FVC and FEV1/FVC after treatment in both groups were significantly higher than those before treatment,and the observation group was significantly higher than the control group,the difference was statistically significant（P<0.05）.Conclusion Budesonide combined with terbutaline compressed atomizing inhalation in the treatment of acute exacerbation of COPD is effective and can significantly alleviate the clinical symptoms and improve pulmonary function,which is worthy of clinical promotion and application. |
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