| Objective To explore the relationship between osteoporosis (OP) and coronary heart disease (CHD) in males using meta-analysis method. Methods International and domestic documentary databases, including Pubmed, Cochrane, Embase, CNKI, Wanfang Data, CQVIP, and CBM, were searched. The retrieval time was from the founding of databases to June 2020. The screened reviews and literature were evaluated according to inclusion and exclusion criteria. The quality of data was assessed according to the Newcastle-Ottawa scale (NOS) and analyzed with a Review Manager 5.3 software. Results A total of 11 papers were included. A total of 1962 patients, 603 cases of osteoporosis, and 1359 cases of non-osteoporosis (osteopenia and normal) were involved. Meta-analysis showed that the incidence of CHD in males was significantly higher in osteoporosis group than that in non-osteoporosis group (OR=1.43, 95%CI 1.14-1.79, P<0.05). In the age-stratified subgroup analysis, there was no statistical significance of occurrence of CHD between osteoporosis and non-osteoporosis group in middle-aged males (OR=0.92, 95%CI 0.23-3.69, P>0.05), while in elderly males the incidence of CHD was much higher (OR=1.86, 95%CI 1.12-3.08, P<0.05). In the subgroup analysis stratified by osteopenia, there was no statistical significance of occurrence of CHD between osteopenia and normal group in middle-aged and elderly males (middle-aged males: OR=1.25, 95%CI 0.66-2.36, P>0.05; elderly males: OR=1.11, 95%CI 0.35-3.53, P>0.05, respectively). Conclusion The incidence of CHD in elderly males is remarkably correlated with osteoporosis, while it is uncorrelated with osteoporosis in middle-aged males. The incidence of CHD is uncorrelated with osteopenia in middle-aged and elderly males. |