超早期强化降压治疗对基底节区脑出血患者的影响

目的分析超早期强化降压治疗对基底节区脑出血患者血浆基质金属蛋白酶(MMP-9)及神经功能的影响。方法选取2015-07-2016-08信阳市第一人民医院收治的脑出血患者90例为研究对象,随机分为2组各45例。对照组给予常规降压治疗,观察组给予强化降压治疗,对比2组治疗前后NIHSS评分、血浆MMP-9水平、水肿量及血肿量。结果2组治疗前NIHSS评分、血浆MMP-9水平、水肿量及血肿量比较,差异无统计学意义(P0.05),治疗后14d,观察组NIHSS评分明显低于对照组,差异有统计学意义(P0.05);治疗后5d,观察组血浆MMP-9水平及水肿量均明显低于对照组,差异有统计学意义(P0.05);治疗后24h,观察组血肿量明显低于对照组,差异有统计学意义(P0.05)。结论超早期强化降压治疗可有效降低血浆MMP-9水平,减轻神经功能缺损,同时减少血肿量及水肿量,对提高患者预后的生活质量具有重要作用。

Effect of ultra-early intensive blood pressure lowering therapy for patients with cerebral hemorrhage in basal ganglion region

Objective To analyze the effect of ultra-early intensive blood pressure lowering therapy on plasma matrix metalloproteinases (MMP-9) and neurologic function in patients with cerebral hemorrhage in basal ganglion region.Methods 90 patients with cerebral hemorrhage in the First People's Hospital of Xinyang from July 2015 to August 2016 were selected,and they were randomly divided into two groups,45 cases in each group.Control group was treated with routine blood pressure lowering therapy,while observation group was treated with intensive blood pressure lowering therapy.The NIHSS score,level of plasma MMP-9,edema volume and hematoma volume before and after treatment were compared between the two groups.Results Before treatment,the NIHSS score,level of plasma MMP-9,edema volume and hematoma volume between two groups had no statistical difference (P＞0.05),and after 14d treatment,the NIHSS score of observation group was significantly lower than that of control group (P＜0.05);After 5d treatment,the level of plasma MMP-9 and edema volume in observation group were lower than those in control group (P＜0.05);After 24h treatment,the hematoma volume of observation group was lower than that of control group (P＜0.05).Conclusion Ultra-early intensive blood pressure lowering therapy can effectively decrease level of plasma MMP-9 and neurologic function deficit,reduce edema volume and hematoma volume and increase quality of life.