血清缺血修饰清蛋白与急性脑梗死的相关性研究

目的探讨血清缺血修饰清蛋白与急性缺血性脑卒中各亚型及患者早期预后的相关性。方法选取我院2013-04-2016-03收治的符合研究标准的104例急性缺血性脑卒中患者为研究组,另选取同期门诊体检健康者54例为对照组。根据英国牛津郡社区脑卒中分型(OCSP)标准将104例急性缺血性脑卒中患者分为腔隙性梗死(LACI)组(n=25)、后循环梗死(POCI)组(n=25)、部分前循环梗死(PACI)组(n=28)、完全前循环梗死(TACI)组(n=26)。抽取各组血清进行检测,对比不同亚型急性缺血性脑卒中患者血清缺血修饰清蛋白水平,并与对照组比较,统计不同亚型急性缺血性脑卒中患者治疗前后神经功能缺损评分(NIHSS)及日常生活活动能力评分(Barthel指数)变化情况。结果 LACI组、POCI组、PACI组、TACI组血清缺血修饰清蛋白水平均明显高于对照组,差异有统计学意义(P0.05);TACI组血清缺血修饰清蛋白水平明显高于LACI组、POCI组、PACI组,差异有统计学意义(P0.05);治疗前各组NIHSS评分及Barthel指数对比差异无统计学意义(P0.05),治疗后各组均较治疗前改善,且TACI组与其余3组对比差异有统计学意义(P0.05)。结论血清缺血修饰清蛋白作为急性缺血性脑卒中分型参考指标,其表达水平与患者预后具有密切相关性,血清缺血修饰清蛋白水平越高,预后效果越差。

Study on correlation between serum ischemia modified albumin and acute ischemic stroke subtypes and prognosis of patients

Objective To investigate the correlation of serum ischemia modified albumin and acute ischemic stroke subtypes and patient prognosis.Methods 104 patients with acute ischemic stroke who were selected from April 2013 to March 2016 in our hospital were selected as the study group,another 54 cases were selected as the control group.According to the Oxfordshire Community Stroke type (OCSP) standard,104 cases of patients with acute ischemic stroke were divided into lacunar infarction (LACI)group (n =25),circulation infarction (POCI) group (n =25),partial anterior circulation infarction (PACI) group (n =28) and complete anterior circulation infarction (TACI) group (n =26).We tested the serum and compared the different subtypes of acute ischemic stroke patients serum ischemia modified albumin level,and compared to the control group,statistical different subtypes of acute ischemic cerebral apoplexy patients before and after treatment the neural function defect score (NIHSS) and activities of daily living ability score (Barthel index) changes.Results LACI group,POCI group,PACI group,TACI group of serum ischemia modified albumin levels were significantly higher than those in the control group,the difference was statistically significant (P ＜0.05).In TACI group,the serum level of ischemia modified albumin was significantly higher than that of the LACI group,POCI group,PACI group,the difference was statistically significant (P＜0.05).Before treatment,there was no significant difference in the NIHSS score and Barthel index (P ＞ 0.05).After treatment,the treatment group were improved after treatment,and the difference between the TACI group and the other three groups was statistically significant (P ＜ 0.05).Conclusion Serum ischemia modified albumin may be as reference index of acute ischemic cerebral apoplexy,and its expression levels and the prognosis of patients with close correlation,the higher serum level of ischemia modified albumin,prognosis is worse.