尼麦角林联合奥拉西坦治疗脑卒中后血管性认知功能障碍

目的观察尼麦角林联合奥拉西坦治疗脑卒中后血管性认知功能障碍的临床疗效。方法将120例脑卒中后认知功能障碍患者随机分为尼麦角林组和联合组,分别给予尼麦角林、尼麦角林联合奥拉西坦治疗,2组均治疗1个月。2组治疗前后采用蒙特利尔认知评估量表(MoCA)进行认知功能评分,比较临床疗效。结果联合组MoCA评分提高的均数为(5.97±2.06)分,高于尼麦角林组的(3.53±1.44)分,MoCA评分的变化最显著,尼麦角林组和联合组差异有统计学意义(t=4.21,P0.01),联合组有效率最高,总有效率为93.3%。结论尼麦角林和奥拉西坦是治疗血管性认知功能障碍(VCI)的有效药物,两者联合用药较单一应用尼麦角林效果好,两者联合使用能显著改善脑卒中后血管性认知功能障碍患者的症状严重程度和生活质量,临床疗效确切。

Nicergoline combined oxiracetam in the treatment of vascular cognitive impairment after stroke

Objective To observe the clinical curative effect of nicergoline combined oxiracetam in the treatment of vascular cognitive impairment after stroke.Methods A total of 120 patients with cognitive impairment were randomly divided into nicergoline group and combination group,the nicergoline group was treated with nicergoline,the combination group was given nicergoline and oxiracetam combined treatment,the two groups were treated for 1 month.The cognitive function scores were cotnpared between the two groups by the Montreal cognitive assessment scale (MoCA) before and after the treatment,and clinical efficacy was compared between the two groups.Results The MoCA score of in the combined group was improved (5.97 ± 2.06),which was higher than (3.53±1.44) in the group,and the difference was statistically significant (t =4.21,P＜0.01).The effective rate of combination group was better than that of the nicergoline group,the difference was statistically significant (P＜0.05).Conclusion Nicergoline combined with oxiracetam has better effect compared to the single application of nicergoline,and can significantly improve the symptoms of vascular cognitive dysfunction after stroke and the quality of life.