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重组组织型纤溶酶原激活剂静脉溶栓治疗后循环脑梗死的疗效及安全性评价
引用本文:贺显君,路文革,张潇,赵明,代全德,张建平.重组组织型纤溶酶原激活剂静脉溶栓治疗后循环脑梗死的疗效及安全性评价[J].中国实用神经疾病杂志,2017,20(4).
作者姓名:贺显君  路文革  张潇  赵明  代全德  张建平
作者单位:河南商丘市第一人民医院神经内科 商丘 476100
摘    要:目的探讨rt-PA(重组组织型纤溶酶原激活剂)静脉溶栓治疗后循环脑梗死的疗效及安全性。方法选取我院2013-09—2015-09收治的62例后循环脑梗死患者,依据治疗方法不同分为常规组与研究组各31例。常规组予以常规治疗,研究组予以rt-PA溶栓治疗。比较2组治疗前后NIHSS(神经功能缺失评分量表)评分,观察2组临床效果、继发性脑出血率及病死率、血管再闭塞发生情况。结果与常规组比较,研究组治疗后NIHSS评分较低,差异有统计学意义(P0.05);研究组总有效率(93.5%)高于常规组(64.5%),差异有统计学意义(P0.05);2组继发性脑出血、血管再闭塞发生率及病死率比较,差异均无统计学意义(P0.05)。结论 rt-PA溶栓治疗后循环脑梗死,可显著改善患者神经功能,临床效果较为显著,且安全性较高,在临床治疗中具有重要意义。

关 键 词:重组组织型纤溶酶原激活剂  静脉溶栓  后循环脑梗死

Efficacy and safety of recombinant tissue-type plasminogen activator applied to intravenous thrombolysis in treat-ment of posterior circulation cerebral infarction
He Xianj un,Lu Wenge,Zhang Xiao,Zhao Ming,Dai Quande,Zhang Jianping.Efficacy and safety of recombinant tissue-type plasminogen activator applied to intravenous thrombolysis in treat-ment of posterior circulation cerebral infarction[J].Chinese Journal of Practical Neruous Diseases,2017,20(4).
Authors:He Xianj un  Lu Wenge  Zhang Xiao  Zhao Ming  Dai Quande  Zhang Jianping
Abstract:Objective To explore the efficacy and safety of rt-PA(recombinant tissue-type plasminogen activator)applied to intravenous thrombolysis in the treatment of posterior circulation cerebral infarction.Methods Sixty-two cases with posterior cir-culation cerebral infarction in our hospital from September 2013 to September 201 5 were selected.According to the different treat-ment methods,they were divided into routine group and study group,31 cases in each group.The routine group was treated by conventional therapy,and the study group was treated with rt-PA thrombolytic therapy.We compared NIHSS scores before and af-ter treatment,clinical effects,secondary cerebral hemorrhage rate,mortality and the occurrence of vascular occlusion between the two groups.Results Compared with the routine group,the NIHSS scores in the study group were lower after treatment,and the difference was statistically significant(P <0.05 ).Furthermore,the study group(93.5%)showed higher total effective rate than the routine group(64.5%)with the significant difference(P <0.05).There were no significant differences as for secondary cerebral hemorrhage rate,incidence of vascular occlusion and mortality between the two groups(P >0.05).Conclusion rt-PA thrombolytic therapy for patients with posterior circulation cerebral infarction can significantly improve the neurological function,has an obvious clinical efficacy and plays an important role in clinical treatment with high safety.
Keywords:Recombinant tissue type plasminogen activator  Intravenous thrombolysis  Posterior circulation cerebral infarc-tion
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