溶栓联合神经保护剂对大鼠脑梗死的保护作用

目的探讨高危儿早期干预降低脑性瘫痪发生率的效果。方法高危儿120例分为早期干预组(60例)和常规组(60例)。干预组除接受常规育儿指导外,还进行综合的康复训练。常规组仅接受常规的育儿指导。结果1岁时脑性瘫痪发生率干预组为3.33%(2/60),常规组为16.67%(10/60),2组比较差异有统计学意义(P<0.05)。结论高危儿早期干预可降低脑瘫的发生率。

Protective effects of the combinative therapy with thrombolysis and neuroprotective on cerebral infarction in ratsLu

Objective To investigate the effect of urokinase(UK) thrombolysis in combination with edaravone on the microvascular basallamina(fibronectin,FN)on acute cerebral ischemia in rats.To approach the possible mechanism of thrombolysis in combination with neuroprotective agent.Methods Sprague-Dawley rats were subjected to middle cerebral artery occlusion(MCAO) by autologous blood embolism.Rats of four groups were studied: rats suffered sham operation(Sham group),untreated ischemia controls(NS group),rats that received UK after ischemia(UK group),rats that received urokinase and edaravone(UK ED group).The infarction volume of brain was investigated by 2,3,5-triphenyl tetrazolium chloride(TTC) coloring.The histological morphlogical damage of brain was investigated by hematoxylin-eosin(HE)staining.The expression of FN of the four groups was analyzed by immunofluorescence 24h after ischemia.Results Cerebral ischemia couldnot be seen in sham operation.Infarction volume was lower both in UK and UK ED compared with NS group(P<0.01),UK ED group was significantly lower(P<0.01).Immunofluorescence revealed basal lamina FN degradation in ischemic groups(all P<0.01),the expression was weaker in UK than NS and UK ED group(P<0.05),NS was weaker than UK ED(P<0.05).Conclusion Edaravone probably enhanced the expressions of fibronectin and relieved brain damage after ischemia/reperfusion.Thus,it has the effects of certain neural protection in thrombolysis.