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同型半胱氨酸与糖尿病周围神经病变的关系
引用本文:盛春燕,尹岭,韩勇,郭清华,陈小星.同型半胱氨酸与糖尿病周围神经病变的关系[J].中国神经科学杂志,2003,19(3):190-193.
作者姓名:盛春燕  尹岭  韩勇  郭清华  陈小星
作者单位:[1]解放军309医院 [2]解放军总医院神经信息中心 [3]解放军总医院内分泌科,北京100091
摘    要:目的:了解血浆同型半胱氨酸(Hcy)与2型糖尿病周围神经病变间的关系及叶酸对Hcy水平的影响和对糖尿病周围神经病变的防治作用。方法:24只糖尿病KKAy小鼠分为3组:糖尿病诱发饮食组(KA组);高蛋氨酸饮食组(KB组);喂养高蛋氨酸饮食的基础上加用叶酸组(Kc组)。16只C57小鼠为正常对照组,分为2组:糖尿病诱发饮食组(CA组);高蛋氨酸饮食组(CB组)。测定血糖、体重、血浆HCY、叶酸浓度,并观察光镜下及电镜下坐骨神经结构变化。结果:糖尿病小鼠喂饲蛋氨酸后出现高Hcy血症,对照组无此改变。糖尿病小鼠的坐骨神经出现不同程度的缺血性改变,且与Hcy水平相关。叶酸可减轻坐骨神经损害的程度。结论:高同型半胱氨酸为糖尿病微血管病变的危险因素,叶酸可起到干预作用。

关 键 词:同型半胱氨酸  周围神经病变  并发症  叶酸  2型糖尿

Plasma homocysteine and peripheral neuropathy of type 2 diabetes
SHENG Chun yan ,YIN Ling ,HAN Yong ,GUO Qing hua ,CHEN Xiao xing.Plasma homocysteine and peripheral neuropathy of type 2 diabetes[J].Neuroscience Bulletin,2003,19(3):190-193.
Authors:SHENG Chun yan  YIN Ling  HAN Yong  GUO Qing hua  CHEN Xiao xing
Institution:SHENG Chun yan 1,YIN Ling 2,HAN Yong 1,GUO Qing hua 3,CHEN Xiao xing 1
Abstract:Objective:To investigate the relationship between the plasma homocysteine and peripheral neuropathy of type 2 diabetes, and the association of plasma homocysteine level with serum folate level.Methods: 24 KKAy mice were divided into three groups: KA high heat diet; KB high heat +methionine diet; KC high heat +methionine+folic acid diet and 16 C 57 mice were divided into two groups: CA high heat diet; CB high heat +methionine diet. The plasma Hcy level, plasma folic acids level were measured and light microscope, electron microscope were used to observe changes of neuropathomorphology of sciatic nerve.Results: 1) The mean plasm level of Hcy was higher in KKAy mice than that in C 57 mice. 2) In KKAy mice ,the structure of sciatic nerve was deteriorated .In the group with hyperhomocysteinemia(HHcy) ,the deficit was the most serious. The folic acids can lighten its deficit. Conclusion:HHcy was a risk for microangiopathy in type 2 diabetes, and folate level influenced the plasma Hcy level in type 2 diabetes.
Keywords:type 2 diabetes  diabetic peripheral neuropathy  homocysteine  KKAy mice
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