Neurotoxicological effects of 3-nitropropionic acid on the neonatal rat |
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Authors: | Wang Ting Zhang Long Jiang Li He Nongyue |
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Institution: | aState Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China;bTeaching and Research Section of Pediatrics, Clinical Medical College, Southeast University, Nanjing 210009, China |
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Abstract: | An increasing amount of data provides support for the hypothesis that periventricular leukomalacia (PVL) results from pre- or perinatal hypoxia occurring and is a major cause of cerebral palsy. In this work, anoxic and hypoxic–ischemic brain injuries were observed by us, after injection of neurotoxin 3-nitropropionic acid (3-NP) in a neonatal rat model on postnatal day 5 (P5). 3-NP-induced brain injury was examined in fixed brain sections at 24 h (P6), 48 h (P7), 72 h (P8), and 9 days (P14) after 3-NP injection, respectively. Injection with 3-NP results in pathological injuries including white matter lesions, cerebral cortex destruction, callose thinness, and cerebral ventricle expansion. Numbers of immature oligodendrocytes turned to less in the model of 3-NP. Furthermore myeline basic protein expression became significantly lower after 3-NP was injected. Pathological changes after injection of 3-NP appeared also significantly among rats of postnatal day 5. The effect of the 3-NP neurotoxicity paradigm was evaluated in this study to further investigate the underlying pathology associated with PVL, which may yield a potential desirable model for clinic experiments. |
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Keywords: | Cerebral palsy Periventricular leukomalacia (PVL) 3-Nitropropionic acid Hypoxia Postnatal day 5 rats |
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