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帕金森病的发病机理:氧化应激,环境影响因素与神经炎症
引用本文:袁红,郑静晨,刘平,张韶峰,许建阳,白丽敏.帕金森病的发病机理:氧化应激,环境影响因素与神经炎症[J].神经科学通报,2007,23(2):125-130.
作者姓名:袁红  郑静晨  刘平  张韶峰  许建阳  白丽敏
作者单位:[1]中国武警总医院中西医结合科,北京100039 [2]哈尔滨医科大学免疫学教研室,哈尔滨150086 [3]北京中医药大学解剖学教研室,北京100029
摘    要:目前,帕金森病的发病机理存在各种假说,包括氧化应激与清除自由基能力下降、线粒体功能异常、兴奋性氨基酸的毒性作用、神经营养因子的缺乏、神经炎症机制、基因与环境影响因素、一氧化氮毒性作用和凋亡等。本文就帕金森病的氧化应激、环境影响因素、神经炎症机制作一综述。

关 键 词:发病机理  帕金森病  氧化应激  神经炎症  环境影响
文章编号:1673-7067(2007)02-0125-06
收稿时间:2006-04-28
修稿时间:2006年4月28日

Pathogenesis of Parkinson’s disease: oxidative stress, environmental impact factors and inflammatory processes
Hong Yuan,Jing-Chen Zheng,Ping Liu,Shao-Feng Zhang,Jian-Yang Xu,Li-Min Bai.Pathogenesis of Parkinson’s disease: oxidative stress, environmental impact factors and inflammatory processes[J].Neuroscience Bulletin,2007,23(2):125-130.
Authors:Hong Yuan  Jing-Chen Zheng  Ping Liu  Shao-Feng Zhang  Jian-Yang Xu  Li-Min Bai
Institution:Department of Integrated Traditional Chinese and Western Medicine, the General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China. hongyuan6@yahoo.com
Abstract:Current hypothesis of neuronal degeneration in Parkinson's disease (PD) have been proposed, including formation of free radicals and oxidative stress, mitochondrial dysfunction, excitotoxicity, trophic factor deficiency, inflammatory processes, genetic factors, environmental impact factors, toxic action of nitric oxide, apoptosis, and so on. This review mainly discussed oxidative stress, environmental impact factors, and inflammatory processes in PD.
Keywords:pathogenesis  Parkinson's disease  oxidative stress  neurogenic inflammation  environmental impact
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