Clinical implications of scalp ictal EEG pattern in patients with temporal lobe epilepsy |
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| Institution: | 1. Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France;2. APHM, Timone Hospital, Epileptology and Cerebral Rhythmology, Marseille, France;3. INSERM U1099, LTSI, Rennes, France;4. Université de Rennes 1, LTSI, Rennes, France;1. Department of Neurology Institute of Neurosciences, QEUH, Glasgow G51 4TF, United Kingdom;2. Department of Clinical Neurophysiology, Institute of Neurosciences, QEUH, Glasgow G51 4TF, United Kingdom;3. Academic Neurology Unit, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, United Kingdom;4. Department of Clinical Neurology, Chalfont Centre for Epilepsy, London, UK;5. School of Medicine, University of Glasgow, G12 8QQ, United Kingdom;1. Department of Functional Neurology and Epileptology, Hospital for Neurology and Neurosurgery Pierre-Wertheimer, hospices Civils de Lyon, 59, boulevard Pinel, 69677 Bron cedex, France;2. Inserm U1028, CNRS 5292, TIGER: Neuroscience research center of Lyon, 69675 Bron cedex, France;3. Paediatric Neurosurgery, Rothschild Foundation Hospital, 25–29, rue Manin, 75019 Paris, France;4. Institut de neurosciences des systèmes, Aix Marseille University, 13005 Marseille, France;5. Service de neurophysiologie clinique, hôpital de la Timone, AP–HM, 13005 Marseille, France;6. Université de Lyon, université Claude-Bernard, 69100 Villeurbanne, France;7. Inserm U1127, CNRS 7225, Brain and Spine Institute, 75013 Paris, France;8. Université Pierre et Marie Curie, Sorbonne Universités, 75252 Paris, France;9. Unit of Epileptology, Department of Neurosurgery, Sainte-Anne Hospital, 75014 Paris, France;10. Department of Neurosurgery, groupe hospitalier universitaire de La Pitié-Salpêtrière, 47–83, boulevard de l’Hôpital, 75013 Paris, France;11. Service de neurochirurgie, hôpital Central, CHU de Nancy, 29, avenue du Maréchal-de-Lattre-de-Tassigny, 54000 Nancy, France;12. Explorations neurophysiologiques, hôpital Purpan, université de Toulouse, 31059 Toulouse, France;13. Department of Neurosurgery, Rouen University Hospital, rue de Germont, 76000 Rouen, France;14. Inserm 1073, Faculty of Medicine, 76183 Rouen, France;15. Inserm ERI 28, Microvascular Endothelium and Neonate Brain Lesions Laboratory, Faculty of Medicine, 76183 Rouen, France;p. Neurology Department, CHU Grenoble-Alpes,38700 La Tronche, France;q. University Grenoble, 38400 Saint-Martin-d''Hères, France;r. Inserm, U1216, Grenoble Institute of Neuroscience (GIN), 38700 La Tronche, France;s. Department of Neurophysiology, Rouen University Hospital, rue de Germont, 76031 Rouen, France;t. Neurology Department, CHU de Nancy, 54000 Nancy, France;u. CRAN UMR 7039, CNRS Lorraine-Université, 54506 Vandoeuvre cedex, France;v. Service épilepsie, sommeil et explorations fonctionnelles neuropédiatriques, HFME, 59, boulevard Pinel, 69677 Bron cedex, France;w. EEG and Epilepsy Unit, groupe hospitalier Pitié-Salpêtrière-Charles Foix, AP–HP, 75013 Paris, France;x. Centre de référence des épilepsies rares, France;y. Brain and Spine Institute (ICM; Inserm, UMRS 1127; CNRS, UMR 7225), 75252 Paris, France;z. Service de neurologie, CHU de Rennes, 2, rue Henri-le-Guilloux, 35033 Rennes cedex 9, France;11. Inserm UMR 1099, Rennes 2, 35043 Rennes cedex, France;12. Department of Neurosurgery, University Hospital, 59037 Lille cedex, France;13. Inserm, U1189-ONCO-THAI-Image Assisted Laser Therapy for Oncology, CHU de Lille, université de Lille, 59000 Lille, France;14. Medical and Surgical Epilepsy Unit, Hautepierre Hospital, University of Strasbourg, 67200 Strasbourg, France;15. Service de neurochirurgie, CHU de Toulouse, université Paul-Sabatier, 31059 Toulouse, France;16. Department of clinical neurophysiology, Lille University Hospital, 59037 Lille cedex, France;17. Inserm U1171, University of Lille, 59000 Lille, France;18. Faculté de médecine Henri-Warembourg, 59045 Lille cedex, France;19. Université de Toulouse, 31013 Toulouse, France;110. CerCo, centre de recherche cerveau et cognition, UMR 5549–CNRS, 31052 Toulouse, France;111. Unité des explorations fonctionnelles neurologiques, CHU de Rennes, 2, rue Henri-le-Guilloux, 35033 Rennes cedex 9, France;112. EA 4712 « Comportement et Noyaux Gris Centraux », faculté de médecine, université de Rennes 1, avenue Léon-Bernard, 35043 Rennes, France;1. Department of Clinical Neuroscience, King’s College London, Institute of Psychiatry, UK;2. Department of Clinical Neurophysiology, King’s College Hospital NHS Trust, London, UK;3. Universidad San Francisco de Quito, School of Medicine, Quito, Ecuador;4. Department of Neuropathology, King’s College Hospital NHS Trust, London, UK;5. Department of Neurosurgery, King’s College Hospital NHS Trust, London, UK;6. Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, Madrid, Spain;7. Serviço de Anatomia Patológica, Hospital Pedro Hispano, Matosinhos, Portugal;1. Institut de neurosciences des systèmes, Aix-Marseille university, 13005 Marseille, France;2. Service de neurophysiologie clinique, hôpital de la Timone, AP–HM, 13005 Marseille, France;3. Service de neurologie, CHU de Rennes, 2, rue Henri-le-Guilloux, 35033 Rennes cedex 9, France;4. Inserm UMR 1099, 35000 Rennes 2, France;5. Medical and surgical epilepsy unit, Hautepierre hospital, university of Strasbourg, 67200 Strasbourg, France;6. Explorations neurophysiologiques, hôpital Purpan, université de Toulouse, 31059 Toulouse, France;7. AP-HP, GH Pitie-Salpêtrière-Charles Foix, Epilepsy Unit and Neurophysiology Department, Paris, France;1. Epilepsy Center, Department of Neurosurgery, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, 79106, Freiburg, Germany;2. Department of Neuroanatomy, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, Albert Strasse 17, 79104, Freiburg, Germany;3. Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, 79106, Freiburg, Germany;4. Center for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, 79106, Freiburg, Germany |
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| Abstract: | ObjectiveTo determine the clinical implications of scalp ictal EEG pattern in patients with temporal lobe epilepsy (TLE).MethodsScalp EEG ictal patterns were retrospectively determined in 27 consecutive patients with medically refractory temporal lobe epilepsy who underwent phase-1 scalp video-EEG and phase-2 simultaneous scalp and intracranial video-EEG recordings for pre-surgical evaluation.ResultsOf the 192 temporal lobe seizures recorded during phase-1 and phase-2 scalp video-EEG studies, 124 (65%) seizures were associated with theta/alpha (5–9 Hz) ictal onset pattern, and 68 (35%) seizures were associated with delta (2–5 Hz) ictal onset pattern. Fourteen (52%) patients had exclusively theta/alpha ictal onset, 3 (11%) patients had exclusively delta ictal onset, and 10 (37%) patients had mixed theta/alpha and delta ictal onsets. MTLE was observed in 26 patients who had 124 seizures with theta/alpha ictal onset and 59 seizures with delta ictal onset. LTLE was observed in one patient who had 9 seizures with delta ictal onset. Scalp ictal EEG pattern was not significantly correlated with postsurgical seizure outcomes.ConclusionsBoth scalp delta and theta/alpha ictal onset patterns can be commonly found in patients with MTLE.SignificanceScalp delta ictal onset is not a unique EEG pattern for LTLE as commonly believed. |
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| Keywords: | Scalp ictal onset Mesial temporal sclerosis Neocortical Depth electrode Temporal lobe epilepsy |
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