The effect of painful laser stimuli on EEG gamma-band activity in migraine patients and healthy controls |
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| Institution: | 1. Department of Data Analysis, Ghent University, Henri Dunantlaan 1, 9000 Gent, België, Belgium;2. Applied Neurophysiology and Pain Unit, SMBNOS Department, Polyclinic General Hospital, Bari Aldo Moro University, Via Amendola 207 A, 70123 Bari, Italy;1. Effat University, College of Engineering, Jeddah 21478, Saudi Arabia;2. Linkoping University, Department of Electrical Engineering, SE-581 83 Linkoping, Sweden;3. University of Toronto, Institute of Biomaterials and Biomedical Engineering, Toronto, ON, Canada;1. INSERM, U1028, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France;2. CNRS, UMR5292, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France;3. Université Lyon 1, Lyon F-69000, France;4. Hospices Civils de Lyon, Croix-Rousse Hospital, Neurology Department, Lyon F-69000, France;5. Tonkin Clinic, Villeurbanne F-69100, France;6. Hospices Civils de Lyon, Neurological Hospital, Functional Neurology and Epileptology Department, Lyon F-69000, France;1. Department of Geriatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, PR China;2. Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, PR China;3. Anti-Aging Monitoring Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, PR China;4. Department of Anti-Aging, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, PR China;5. Shandong Provincial Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250021, Shandong, PR China;1. Department of Neuroscience and Experimental Therapeutics, Albany Medical College, NY, USA;2. Nuvasive Clinical Services, San Diego, CA, USA;3. Department of Neurosurgery, Albany Medical Center, NY, USA;1. Applied Neurophysiology and Pain, Bari Aldo Moro University Bari, Italy;2. U.O. Neurologia III, IRCCS Fondazione Istituto Neurologico “Carlo Besta”, Milan, Italy |
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| Abstract: | ObjectiveGamma-band oscillations (GBOs) induced by nociceptive stimuli were compared between migraine patients and controls in order to further characterize interictal pain processing in the brain of migraineurs. GBOs were related to subjective pain intensity, years of migraine history and migraine attack frequency and the sources of GBOs were investigated.MethodsTwenty-three migraine patients without aura and 23 controls received a series of laser stimulations on their right forehead and right hand while recording electroencephalographic data (61 electrodes). After each series they indicated the perceived pain. A multitaper time-frequency method was used on artifact-cleaned scalp data and frequency domain beamforming was used to localize the GBOs.ResultsIn both groups we observed increases in GBOs around central electrodes, which were not significantly different between groups. The central GBOs were positively associated with the subjective pain ratings in the control group, in accordance with previous studies, but not in the migraine group. Increases in gamma power were observed in the midcingulate cortex.ConclusionsNo evidence was found that GBOs differ between interictal migraine and controls nor that central GBOs represent a neurophysiological correlate of subjective pain in migraine.SignificanceWe shed light on observations of GBOs during pain processing in interictal migraine. |
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| Keywords: | EEG Thermonociceptive stimulation Pain Gamma-band oscillations High-frequency neural activity Migraine |
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