Reduced plasma total antioxidant status in first-episode drug-naive patients with schizophrenia |
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Authors: | Li Xue Feng Zheng You Lan Xiu Mei Hong Chen Da Chun Kosten Thomas R Zhang Xiang Yang |
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Affiliation: | a College of Chinese Medicinal Material, Jilin Agricultural University, ChangChun, Chinab Center for Psychiatric Research, Beijing Huilongguan Hospital, Beijing, Chinac Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA |
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Abstract: | Excessive free radical production leading to oxidative stress may be involved in the pathophysiology of schizophrenia. Determination of total antioxidant status (TAS) provides an index of the sum of activities of all antioxidants. However, there have been few systematic studies to examine the relationship between TAS levels and psychopathology in first-episode and drug-naive patients with schizophrenia.TAS levels were determined in the plasma of 60 never-medicated first-episode patients with schizophrenia and 68 healthy control subjects. The schizophrenia symptomatology and the depressive symptoms were assessed by the positive and negative syndrome scale (PANSS) and the Hamilton rating scale for depression (HAMD). The results showed that TAS levels were significantly lower in first-episode patients with schizophrenia than in healthy control subjects (159.8 ± 45.8 U/ml vs 211.4 ± 46.8 U/ml, F = 39.5, df = 1, 126, p < 0.001). A trend toward significant inverse correlation between TAS levels and PANSS negative subscore was observed (r = 0.25, df = 60, p = 0.06). Our results suggest that oxidative stress occurs in an early course of schizophrenia and may have an important role in pathogenesis and perhaps, negative symptomatology of schizophrenia. |
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Keywords: | ANOVA, analysis of variance BMI, body mass index CNS, central nervous system CSF, central spinal fluid FEP, first-episode psychosis FRAP, ferric reducing antioxidant potential HAMD, Hamilton rating scale for depression LSD, least significant difference PANSS, positive and negative syndrome scale SOD, superoxide dismutase SCID, Structured Clinical Interview for DSM-IV TAS, total antioxidant status |
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