Disrupted regional homogeneity in treatment-resistant depression: a resting-state fMRI study |
| |
Authors: | Guo Wen-bin Sun Xue-li Liu Ling Xu Qiang Wu Ren-rong Liu Zhe-ning Tan Chang-lian Chen Hua-fu Zhao Jing-ping |
| |
Institution: | a Mental health Institute, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, Chinab Mental Health Center, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, Chinac Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, Chinad Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, Chinae Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China |
| |
Abstract: | BackgroundUsing a newly developed regional homogeneity (ReHo) approach, we were to explore the features of brain activity in patients with treatment-resistant depression (TRD) in resting state, and further to examine the relationship between abnormal brain activity in TRD patients and specific symptom factors derived from ratings on the Hamilton Rating Scale for Depression (HRSD).Methods24 patients with TRD and 19 gender-, age-, and education-matched healthy subjects participated in the fMRI scans.Results- 1.
- Compared with healthy controls, decreased ReHo were found in TRD patients in the left insula, superior temporal gyrus, inferior frontal gyrus, lingual gyrus and cerebellum anterior lobe (culmen) (p < 0.05, corrected).
- 2.
- Compared with healthy controls, increased ReHo were found in the left superior temporal gyrus, cerebellum posterior lobe (tuber), cerebellum anterior lobe (culmen), the right cerebellar tonsil and bilateral fusiform gyrus (p < 0.05, corrected).
- 3.
- There was no correlation between the ReHo values in any brain region detected in our study and the patients' age, years of education, illness duration, HRSD total score and its symptom factors.
LimitationThe influence of antidepressants to the brain activity in TRD patients was not fully eliminated.ConclusionsThe pathogenesis of TRD may be attributed to abnormal neural activity in multiple brain regions. |
| |
Keywords: | fMRI functional magnetic resonance imaging ReHo regional homogeneity TRD treatment-resistant depression HRSD Hamilton Rating Scale for Depression MDD major depressive disorder ADHD attention deficit hyperactivity disorder BOLD blood oxygen level-dependent KCC Kendall's coefficient of concordance GE General Electric TR repetition time TE echo time FOV field of view SPM statistical parametric mapping Hz Hertz PET positron-emission tomography SPECT signal photon emission computed tomography EEG electroencephalograph |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|